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Merck

178385

Apocynin

≥98% (GC), powder, NADPH oxidase inhibitor, Calbiochem®

Synonyma:

Apocynin, 4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V

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Vybrat velikost

1 G

3 830,00 Kč

3 830,00 Kč

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O této položce

Empirický vzorec (Hillův zápis):
C9H10O3
Číslo CAS:
498-02-2
Molekulová hmotnost:
166.17
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD00008747
Assay:
≥98% (GC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze
protect from light

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Název produktu

Apocynin, A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

SMILES string

O(C)c1c(ccc(c1)C(=O)C)O

InChI

1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

InChI key

DFYRUELUNQRZTB-UHFFFAOYSA-N

description

Merck USA index - 14, 741

assay

≥98% (GC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white to brown

solubility

DMSO: 10 mg/mL
ethanol: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Související kategorie

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Tato položka
PHL83252A10809W508454
Apocynin A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

Sigma-Aldrich

178385

Apocynin

Apocynin phyproof® Reference Substance

PHL83252

Apocynin

4′-Hydroxy-3′-methoxyacetophenone 98%

Sigma-Aldrich

A10809

4′-Hydroxy-3′-methoxyacetophenone

Acetovanillone ≥98%, FG

Sigma-Aldrich

W508454

Acetovanillone

assay

≥98% (GC)

assay

≥95.0% (HPLC)

assay

98%

assay

≥98%

form

powder

form

solid

form

powder

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

PhytoLab

manufacturer/tradename

-

manufacturer/tradename

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

400

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

-

solubility

DMSO: 10 mg/mL, ethanol: 20 mg/mL

solubility

-

solubility

-

solubility

-

Biochem/physiol Actions

Cell permeable: yes
Primary Target
NADPH oxidase
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).

Other Notes

Abid, M.R., et al. 2000. FEBS Lett.486, 252.
Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932.
Lapperre, T.S., et al. 1999. FEBS Lett.443, 235.
Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.
van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67.
Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Skladovací třída

11 - Combustible Solids

wgk

WGK 2

Osvědčení o analýze (COA)

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Pathways and Biomarkers of Oxidative Stress

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."

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