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104648

Cellvento® ModiFeed Gal- COMP

Chemically defined cell culture feed - EMPROVE® CCM

greener alternative

Greener Alternative

Synonym(s):

Animal-Free Fed-Batch CHO Feed, CHO Glycosylation Control Feed, Cellvento® ModiFeed Gal, Galactosylation-Reducing CHO Feed, Glycan Modulation Feed, Low Galactosylation CHO Feed

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Size/SKUAvailabilityPrice
1 L
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8 540,00 CZK
5 L
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37 000,00 CZK
50 L
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352 500,00 CZK

About This Item

UNSPSC Code:
41106213

8 540,00 CZK


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Product Name

Cellvento® ModiFeed Gal- COMP, Chemically defined, CHO fed-batch feed for galactosylation reduction, EMPROVE® CCM

Quality Segment

biological source

non-animal source

description

shipped with cooling packs

product line

Cellvento®

form

compacted dry powder

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cell culture | mammalian: suitable

application(s)

pharma/biopharma processes

components

glucose: no

greener alternative category

storage temp.

2-8°C

General description

We are committed to bringing you Greener Alternative Products, which belongs to one of the four categories of greener alternatives. This product is a Design for Sustainability (DfS) developed product. Click here to view its DfS scorecard.
Cellvento® ModiFeed Gal- COMP is a chemically defined, animal-component-free cell culture feed developed for CHO fed-batch bioprocessing and targeted control of terminal galactosylation. As part of the Cellvento® ModiFeed platform, this highly concentrated, compacted dry powder is a complete, single-part, pH-neutral feed that replenishes essential nutrients while supporting increased G0(F) and reduced G1(F)/G2(F) glycan levels. The formulation contains no glucose, hydrolysates, phenol red, or 2-mercaptoethanol (2-ME), helping simplify feed preparation and process integration. On combination with Cellvento® ModiFeed Prime it allows tunable galactosylation.

Cellvento® ModiFeed Gal- COMP is supported by the Emprove® Program and designated DfS, making it suitable for scalable, quality-focused biologics manufacturing workflows.

Application

Cellvento® ModiFeed Gal- COMP Suitable for:
  • Monoclonal antibody (mAb) development and commercial manufacturing in Chinese hamster ovary (CHO) cell-based expression systems
  • Biosimilar development requiring precise control over galactosylation profiles to match originator reference product glycan fingerprints
  • Upstream fed-batch bioprocessing where reduced terminal galactosylation is a critical quality attribute (CQA) — formulated to increase G0(F) while decreasing G1(F)/G2(F)
  • Next-generation biopharmaceutical production — including advanced therapeutic proteins requiring defined glycan profiles
  • CHO suspension cell lines including CHO-S, CHO-DHFR⁻, CHO-K1, CHO-GS, and CHOZN®
  • Process intensification strategies requiring high-concentration, reduced-volume feeding to maximize volumetric productivity in bioreactor cultures
  • Mixed feed glycosylation tuning — combinable with Cellvento® ModiFeed Prime COMP to titrate and dial in a target galactosylation level across a continuous G0F–G2F spectrum
  • Compatible with Cellvento® 4CHO COMP and EX-CELL® Advanced CHO production media for a fully integrated, chemically defined upstream process platform

Features and Benefits

  • One-part, pH-neutral complete feed for simplified fed-batch process
  • Maximizes terminal galactosylation without compromising titer
  • Highly concentrated to reduce feed volume added to bioreactor
  • Compacted powder for convenient handling and easy hydration
  • Ambient-stable hydrated solution up to 30 days
  • Chemically defined, no animal-origin components
  • No glucose enabling precise glucose control
  • Supported by EMPROVE® CCM Program

Preparation Note

Formulated to contain 143.6 grams of powder per liter of feed.

Legal Information

CELLVENTO is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

11 - Combustible Solids

wgk

WGK 3


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

7790-84-3

CAS No.


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