Merck

Virus Filters

Viresolve® Barrier capsules and Viresolve® Pro Devices used to assure viral safety in cell culture media and downstream processing

Viral safety is a key consideration in biomanufacturing and is critical to assuring drug safety for patients. Virus filtration, or nanofiltration, separates viruses based on size and is an important component of viral safety assurance in downstream processing. Our trusted Viresolve® solutions are the standard setting products your work deserves.


VIRESOLVE® PRO SOLUTION FOR DOWNSTREAM VIRUS FILTRATION

The Viresolve® Pro Solution provides a comprehensive flexible template for viral clearance in downstream processing of both monoclonal antibodies (mAbs) and recombinant proteins. This proven virus filtration solution delivers the highest levels of virus retention and productivity across a broad range of operating conditions.

Key benefits include:

  • High mass capacity for improved process economics
  • High flux for faster processing
  • Consistent batch-to-batch performance
  • Robust virus retention: ≥ 4 log removal of parvovirus

These disposable filters are easy to use and are offered in small-scale formats for process development and viral clearance studies, as well as larger formats for pilot and commercial manufacturing. All Viresolve® Pro Devices are 100% integrity tested in manufacturing, ensuring quality and consistency.

Prefilters for consistent filtration performance

Prefilters bind protein aggregates and other process impurities that limit the capacity of small-pore virus filters such as the Viresolve® Pro Device. Implementing prefilters improves the capacity and consistency of virus filtration operations. Our prefilter portfolio includes:

  • Viresolve® Pro Shield: surface modified membrane filter with cation exchange adsorptive chemistry, offering caustic stability and low extractables
  • Viresolve® Pro Shield H: surface modified membrane filter with mixed-mode adsorptive chemistry, offering caustic stability and low extractables
  • Viresolve® Prefilter: adsorptive depth filter enabling mixed mode adsorptive and hydrophobic binding, offering autoclave compatibility

These disposable filters are easy to use and are offered in small-scale formats for process development and viral clearance studies, as well as larger formats for pilot and commercial manufacturing.

Quality Standards and Documentation

Viresolve® filters are supported by the Emprove® Program which provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format.

The Viresolve® Pro Solution complements our broad portfolio of products and services, supported by teams with decades of technical expertise providing complete solutions to meet your viral safety needs.


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