[Skip to Content](https://www.sigmaaldrich.com#main-content) [](https://www.sigmaaldrich.com/CZ/en) Products Cart0 CZEN Products ProductsApplicationsServicesResourcesSupport [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/CZ/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/CZ/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/CZ/en)[Solid Phase Microextraction (SPME)](https://www.sigmaaldrich.com/CZ/en/applications/analytical-chemistry/sample-preparation/solid-phase-microextraction)Headspace Sampling of VOCs with SPME # Headspace Sampling of VOCs with SPME [Learn More About SPME](https://www.sigmaaldrich.com/CZ/en/applications/analytical-chemistry/sample-preparation/solid-phase-microextraction) Headspace sampling with SPME is the preferred method to extract volatile organic compounds. Begin the extraction process by placing the sample into the vial puck on the hotplate and index the vial to the sampling position. Insert the holder into the sampling stand, passing the needle through the septum that seals the sample vial. When sampling a liquid, position the SPME fiber in the headspace just above the stirring vortex of the liquid sample. If a solid sample is to be extracted, position the SPME fiber above the surface of the solid without touching it. Retract the fiber into the protective needle and transfer it to the GC injection port. __Related Articles__ - [Biodiesel](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/gas-chromatography/biodiesel) - [Automated Solid Phase Microextraction (SPME) Sampling](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/automated-spme-sampling) - [Bioanalysis with SPME](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/bioanalysis-with-spme) - [BioSPME for Plasma Protein Binding Assay: Details of Method Development and Optimization](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/biospme-plasma-protein-binding-assay) - [Solid Phase Microextraction: Frequently Asked Questions](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/faq) - [GC/MS/MS Analysis of BPA in Energy Drink](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/gc-ms-ms-analysis-of-bisphenol-a-bpa-in-a-fruit-flavored-energy-drink-cla010218a) - [Rugged SPME Sampling](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/nitinol-core-spme-fibers) - [SPME Fiber Performance Tips for Volatiles & Semi-Volatiles](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/solid-phase-microextraction/performance-tips) - [View More](https://www.sigmaaldrich.com/CZ/en/search/facet-search?focus=sitecontent&term=facet-search) Top __Sign In To Continue__ To continue reading please sign in or create an account. 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