[Skip to Content](https://www.sigmaaldrich.com#main-content) [](https://www.sigmaaldrich.com/CZ/en) Products Cart0 CZEN Products [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/CZ/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/CZ/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/CZ/en)[Polymerase Chain Reaction Applications](https://www.sigmaaldrich.com/CZ/en/applications/genomics/pcr)Proligo® Manufacturing Site - Hamburg # Oligonucleotide Reagents Manufacturing Site - Hamburg ## State-of-the-Art Production The Oligonucleotide reagents manufacturing site in Hamburg, Germany is designed as a multi-purpose facility with built-in flexibility and the capability to manufacture a complex mix of products to suit a variety of customer needs. DNA and RNA phosphoramidites are manufactured in glass-lined reactors and purified by preparative column chromatography on silica gel with medium-to-high pressure chromatography equipment. The Hamburg facility has the flexibility to prepare and purify alternative mixes of high volume standard products as well as small-scale specialties. ## Take a Tour of the Production Site ### Hamburg facility at a glance: __Process Technology and R&D__ - 3 labs dedicated to R&D and PT - Scale from mg to kg __Production and Purification__ - Lab production up to __20L reaction__ volume - Bulk production up to __2500L reaction__ volume - 3 automated prep. HPLC with 10 to 45 cm column diameter - >__12.000 kg/year__ amidite purification capacity - Capacity increasing annually __Finished Goods__ - 250 bulk products, 910 finished products, custom capabilities - Dedicated powder filling department and  production unit for liquid products __Quality__ - 3 labs dedicated for QC and analytical development ## MOST EXPERIENCED AMIDITE MANUFACTURER IN THE MARKET Over 40 years’ experience in the manufacture of Oligonucleotide reagents: - Phosphoramidites - Liquid reagents including bulk returnable drums - CPG Annual amidite production capacity is more than __12 tons and increasing annually__, to meet the growing industry demands. All __critical raw materials are dual sourced__ to ensure continuity of supply  Hamburg, Germany Telephone: +49-40-797-02-250 [Email](mailto:deuham-cs@merckgroup.com) ### Contact Us Fields indicated by an * are required. __Related Articles__ - [Milli-Q® IQ 7000 Ultrapure Water System](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/small-molecule-hplc/milli-q-iq-7000) - [Milli-Q® IQ 7003/05/10/15 Ultrapure & Pure Lab Water Purification System](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/analytical-chemistry/wet-chemical-analysis/milli-q-iq7003-7005) - [Custom Oligos for Commercial Use](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/genomics/iso-oligos) - [Custom LAMP Primers in Partnership with New England Biolabs](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/genomics/pcr/custom-lamp-primers) - [Easy Oligo](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/genomics/pcr/easy-oligo) - [Fast siRNA](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/genomics/pcr/fast-sirna-oligos) - [Scalable, High-Quality Custom Oligonucleotides for Commercial PCR, qPCR & NGS](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/genomics/pcr/iso-oligos) - [KOD One™ PCR Master Mix for Ultra-Fast, High-Fidelity PCR](https://www.sigmaaldrich.com/CZ/en/technical-documents/technical-article/genomics/pcr/kod-one-pcr-master-mix) - [View More](https://www.sigmaaldrich.com/CZ/en/search/facet-search?focus=sitecontent&term=facet-search) Top __Sign In To Continue__ To continue reading please sign in or create an account. Sign In__Don't Have An Account?__Register An unknown error has occured.