A6636

Aflatoxin B₁

from Aspergillus flavus, ≥98.0% (HPLC), powder, CYP1A2, CYP2A6, CYP2D6, and CYP3A family substrate

• Empirische Formel (Hill-System): C₁₇H₁₂O₆
• CAS Number: 1162-65-8
• Molekulargewicht: 312.27
• Beilstein: 1269174
• EG-Nummer: 214-603-3
• MDL-Nummer: MFCD00869647
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24891116
• NACRES: NA.77

Eigenschaften

• Product Name: Aflatoxin B₁, from Aspergillus flavus
• Biologische Quelle: Aspergillus flavus
• Qualitätsniveau: 300
• Assay: ≥98.0% (HPLC)
• Form: powder
• Grünere Alternativprodukt-Bewertung: old score: 51; new score: 42; Find out more about DOZN™ Scoring
• Grünere Alternativprodukt-Eigenschaften: Waste Prevention; Designing Safer Chemicals; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• Grünere Alternativprodukt-Kategorie: Re-engineered,
• Lagertemp.: 2-8°C
• SMILES String: COc1cc2OC3OC=CC3c2c4OC(=O)C5=C(CCC5=O)c14
• InChI: 1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
• InChIKey: OQIQSTLJSLGHID-WNWIJWBNSA-N

Beschreibung

Allgemeine Beschreibung

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Designing Safer Chemicals” and “Design for Energy Efficiency”. Click here to view its DOZN scorecard.

Anwendung

Aflatoxin B1 is a carcinogenic compound that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 may be used as an internal standard when testing for aflatoxin contamination in food products.

Biochem./physiol. Wirkung

Aflatoxin B1 is a carcinogenic compound produced by Aspergillus flavus, a common soil fungus, that induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. Aflatoxin B1 is a food contaminant and a hepatocarcinogen. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR). Aflatoxin B1 is a CYP1A2, CYP2A6, CYP2D6, and CYP3A family substrate.

Warnhinweis

Möglicherweise karzinogen

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H340,H350
• P-Sätze: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Carc. 1B - Muta. 1B
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges