I9910

Ibutilid -hemifumarat (Salz)

≥98% (HPLC)

• Synonym(e): (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt, Corvert
• Empirische Formel (Hill-System): C₂₀H₃₆N₂O₃S · 0.5C₄H₄O₄
• CAS Number: 122647-32-9
• Molekulargewicht: 442.61
• MDL-Nummer: MFCD01715410
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329815470
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: off-white to tan
• Löslichkeit: H₂O: >20 mg/mL
• Lagertemp.: room temp
• SMILES String: OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1.CCCCCCCN(CC)CCCC(O)c2ccc(NS(C)(=O)=O)cc2
• InChI: 1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChIKey: PCIOHQNIRPWFMV-WXXKFALUSA-N
• Angaben zum Gen: human ... KCNH2(3757)

Beschreibung

Biochem./physiol. Wirkung

Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent.

Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent. Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H361d
• P-Sätze: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Repr. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable