SML0202

DPH

Name: DPH
Brand: SIGMA
Price: 95.2 EUR
Availability: InStock

≥98% (HPLC)

Synonym(e):

5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₈H₁₃FN₄O₂

CAS-Nummer:

484049-04-9

Molekulargewicht:

336.32

MDL-Nummer:

MFCD03268950

UNSPSC-Code:

12352200

PubChem Substanz-ID:

329825226

NACRES:

NA.77

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Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to tan

Löslichkeit

DMSO: ≥10 mg/mL

Lagertemp.

2-8°C

SMILES String

Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4

InChI

1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)

InChIKey

MPQWYPLPWGUMJE-UHFFFAOYSA-N

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Dieser Artikel	SML0235	SML1693	SML2226
Sigma-Aldrich SML0202 DPH	Sigma-Aldrich SML0235 CDPPB	Sigma-Aldrich SML1693 Pz-1	Sigma-Aldrich SML2226 BC-LI-0186
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: ≥10 mg/mL	solubility DMSO: ≥5 mg/mL at warmed to 60 °C	solubility DMSO: 1 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear
color white to tan	color white to beige	color white to beige	color white to beige

Anwendung

DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies.

Biochem./physiol. Wirkung

DPH binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. It exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl.[1]

DPH is a potent cell permeable c-Abl activator. DPH binds to the myristoyl binding site and leads to activation of c-Abl kinase activity. The compound stimulates the phosphorylation of c-Abl and its downstream substrate Crk.

Potent cell permeable c-Abl activator

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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DPH