SML0370

Kartogenin

Name: Kartogenin
Brand: SIGMA
Price: 107 EUR
Availability: InStock

≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder

Synonym(e):

2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₀H₁₅NO₃

CAS-Nummer:

4727-31-5

Molekulargewicht:

317.34

MDL-Nummer:

MFCD00560510

UNSPSC-Code:

12352200

PubChem Substanz-ID:

329825371

NACRES:

NA.77

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Produktname

Kartogenin, ≥98% (HPLC)

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

DMSO: >15 mg/mL

Lagertemp.

room temp

SMILES String

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O

InChI

1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)

InChIKey

SLUINPGXGFUMLL-UHFFFAOYSA-N

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Dieser Artikel	C8249	SML0773	SML0927
Sigma-Aldrich SML0370 Kartogenin	Sigma-Aldrich C8249 Kardamonin	Sigma-Aldrich SML0773 GSK-650394	Sigma-Aldrich SML0927 Diapocynin
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
solubility DMSO: >15 mg/mL	solubility DMSO: ≥20 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 2 mg/mL, clear (warmed)

Biochem./physiol. Wirkung

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes.

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

Kartogenin is a small heterocyclic compound.[1] It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.[2]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

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Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome.

Jun Zhao et al.

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Disordered folliculogenesis is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear. Long non-coding RNA (lncRNA) expression in luteinized granulosa cells (hLGCs) derived from women with and without PCOS were analyzed using microarray and

11-Ketotestosterone Is a Major Androgen Produced in Human Gonads.

Yoshitaka Imamichi et al.

The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)

11-ketotestosterone (11-KT) is a novel class of active androgen. However, the detail of its synthesis remains unknown for humans. The objective of this study was to clarify the production and properties of 11-KT in human. Design, Participants, and Methods: Expression

Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells.

Alix Barbe et al.

International journal of molecular sciences, 20(17) (2019-08-31)

Reactive oxygen species (ROS) which lead to oxidative stress affect ovarian function. Grape seed extract (GSE) could be proposed as an effective antioxidant, particularly due to its proanthocyanidin content. In this study, we investigated a dose effect (0, 0.01, 0.1

miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.

Mei Zhang et al.

Cell death & disease, 8(10), e3088-e3088 (2017-10-06)

Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here

A Novel Approach for Meniscal Regeneration Using Kartogenin-Treated Autologous Tendon Graft.

He Huang et al.

The American journal of sports medicine, 45(14), 3289-3297 (2017-09-02)

The meniscus is one of the most commonly injured parts of the body, and meniscal healing is difficult. Kartogenin (KGN) induces tendon stem cells (TSCs) to differentiate into cartilage cells in vitro and form meniscus-like tissue in vivo. A damaged

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Kartogenin