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Showing 1-30 of 92 results for "107-15-3" within Papers
Luca Gianni et al.
The Lancet. Oncology, 13(1), 25-32 (2011-12-14)
Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and
B Kögel et al.
Arzneimittel-Forschung, 49(8), 679-684 (1999-09-14)
The inotropic efficacy, arrhythmogenicity and cardiohaemodynamic properties of AL 107 (3-alpha-methyl-digitoxigenin glucoside, CAS 62190-59-4), a novel cardiac glycoside, were studied in anaesthetized dogs with pentobarbital-induced acute cardiac insufficiency. Three groups of dogs received AL 107, ouabain or verhicle. The cardiac
Satoshi Fukuda et al.
Scientific reports, 11(1), 23966-23966 (2021-12-16)
In sepsis, microvascular hyperpermeability caused by oxidative/nitrosative stress (O&NS) plays an important role in tissue edema leading to multi-organ dysfunctions and increased mortality. We hypothesized that a novel compound R-107, a modulator of O&NS, effectively ameliorates the severity of microvascular
Yosuke Doi et al.
Cancer science, 101(6), 1529-1535 (2010-04-07)
Vascular endothelial growth factor receptors (VEGFRs) are mainly expressed by endothelial cells, but they are also expressed by some cancer cells, including pancreatic cancer. The objective of this study was to evaluate the significance of VEGFRs expression in pancreatic cancer
Alexander J Stratigos et al.
The Journal of investigative dermatology, 126(2), 399-401 (2005-12-24)
The genetic basis of melanoma susceptibility among Greek patients is uncharacterized. From 107 consecutive cutaneous melanoma patients, we analyzed the CDKN2A and CDK4 loci among 18 early-onset (< or =40 years) and two multiplex melanoma cases. Overall, we found three
Ponnusamy Vinay et al.
Journal of molecular neuroscience : MN, 71(1), 28-41 (2020-06-23)
This study was designed to test whether the Cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of the complement system; subsequent activation of inflammatory signals leads to alternations in serotonin transporter (SERT). To test this, rat
M F Kohler et al.
Cancer research, 52(6), 1622-1627 (1992-03-25)
Immunohistochemical staining for the p53 protein was performed in 107 snap frozen primary endometrial adenocarcinomas and 15 benign uterine tissues using monoclonal antibody PAb1801. No staining was seen in benign samples, whereas intense nuclear staining of cancer cells consistent with
Eva Potura et al.
Anesthesia and analgesia, 120(1), 123-129 (2014-09-05)
Recent studies have shown a decline in glomerular filtration rate and increased renal vasoconstriction after administration of normal saline when compared with IV solutions with less chloride. In this study, we investigated the impact of normal saline versus a chloride-reduced
Kathryn Gill et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 16(5), 319-331 (2005-08-18)
The objective of the present study was to map quantitative trait loci (QTL) for alcohol intake using A x B/B x A recombinant inbred (RI) and AcB/BcA recombinant congenic (RC) strains of mice that were independently derived from the A/J
Cheng-Hsin Chu et al.
Journal of gastroenterology and hepatology, 24(9), 1559-1561 (2009-06-03)
The gene product of the uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is crucial to bilirubin metabolism. Mutations in this gene subsequently result in disease presented with unconjugated hyperbilirubinemia. A previous study showed that a TA-repeat polymorphism in the promoter region
Heiner K Berthold et al.
Scandinavian cardiovascular journal. Supplement, 47(1), 20-27 (2012-09-28)
Statins decrease cardiovascular events mainly by lowering cholesterol but anti-inflammatory effects also play a role. The effects of the cholesterol absorption inhibitor ezetimibe on markers of inflammation remain unclear. We performed an exploratory post-hoc analysis whether these drugs influence the
Alexander L Shifrin et al.
Surgery, 148(6), 1274-1280 (2010-12-08)
Single nucleotide polymorphisms (SNPs) may function as modifiers of the RET proto-oncogene, resulting in the expression of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). We present 2 non-related Italian-American families (Family 1, n = 107; Family 2, n
Jamile Zeni et al.
Applied biochemistry and biotechnology, 163(3), 383-392 (2010-07-30)
The aim of this work was to perform the screening of microorganisms, previously isolated from samples of agro-industrial waste and belonging to the culture collection of our laboratory, able to produce polygalacturonases (PG). A total of 107 microorganisms, 92 newly
Yajie Sheng et al.
Toxicon : official journal of the International Society on Toxinology, 60(7), 1245-1250 (2012-09-11)
Fumonisin B₁ (FB₁) is a mycotoxin, mainly produced by Fusarium fungi and present in food and feed. It causes harmful effects on human and animal health. Therefore, it is necessary to develop sensitive and reliable screening methods. In this study
Kristina Ryberg et al.
Contact dermatitis, 58(4), 199-209 (2008-03-21)
Contact allergy to textile dyes is not uncommon. The allergy is detected by patch testing patients with commercial patch test preparations. To investigate 8 disperse dyes (DDs) used for patch testing in the departments in Malmö and in Leuven and
Jin C Kim et al.
Familial cancer, 3(2), 129-137 (2004-09-02)
The genotypic consequences of numerous single-nucleotide variants in human mismatch repair genes are mostly undetermined. We examined 27 reported single-nucleotide variants, rarely or ambiguously verified in a population-based study, to identify single-nucleotide polymorphisms (SNPs), haplotypes, and the genotype-phenotype association in
Yong Gu Cho et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 115(7), 802-808 (2007-07-07)
KLF4, which is also known as the gut-enriched Kruppel-like factor, plays important roles during the proliferation and differentiation of gastrointestinal epithelial cells. A loss of KLF4 expression has been observed in human tumors, particularly in the gastrointestinal tract. In this
C B'Hymer
Journal of chromatographic science, 46(5), 369-374 (2008-05-22)
A static headspace gas chromatographic method is developed and evaluated for the quantitation of residual 2-propanol, methanol, and toluene in bulk (2alpha, 6alpha, 8alpha, 9alpha beta)-octahydro-3-oxo-2,6-methanon-2H-quinolizin-8-yl-1H-indole-3-caboxylate methanesufonate hydrate, a serotonin 5-HT3 receptor antagonist drug compound. This method is accurate and
Masatsugu Hiraki et al.
Annals of surgical oncology, 18(10), 3013-3019 (2011-03-17)
To assess whether gene methylation in peritoneal fluid (PF) is clinically feasible for determining micrometastasis to the peritoneum in gastric cancer. The gene methylation of BNIP3, CHFR, CYP1B1, MINT25, SFRP2, and RASSF2 were analyzed in 107 specimens of PF by
Ji-Youn Han et al.
Lung cancer (Amsterdam, Netherlands), 63(1), 115-120 (2008-01-29)
To define an integrated pharmacogenetic model for predicting irinotecan pharmacokinetic (PK) and severe toxicity, we evaluated multivariate analysis using 15 polymorphisms within seven genes with putative influence on metabolism and transport of irinotecan. A total of 107 NSCLC patients treated
K P Sharon et al.
Journal of dairy science, 102(10), 9082-9096 (2019-08-12)
The objectives of this study were to determine whether plane of nutrition (PON) of milk replacer previously provided to calves, and dosage level of Mannheimia haemolytica (MH), influenced inflammatory responses to a combined viral-bacterial respiratory challenge. Holstein calves (1 d
Nirajkumar Makadiya et al.
The Journal of general virology, 96(9), 2749-2763 (2015-06-03)
The L6 region of bovine adenovirus type 3 (BAdV-3) encodes a non-structural protein named 100K. Rabbit antiserum raised against BAdV-3 100K recognized a protein of 130 kDa at 12-24 h and proteins of 130, 100, 95 and 15 kDa at 36-48 h after BAdV-3
Cristina Cunha et al.
The New England journal of medicine, 370(5), 421-432 (2014-01-31)
The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity. The contribution of single-nucleotide polymorphisms (SNPs) in PTX3 to the development of invasive aspergillosis is unknown. We screened an initial cohort of 268
Michela Mazzocco et al.
Gene, 291(1-2), 233-239 (2002-07-04)
The SH3 binding glutamic acid-rich (SH3BGR) gene was cloned in an effort to identify genes located to human chromosome 21, within the congenital heart disease region, and expressed in the developing heart. After the identification of SH3BGR, two human homologous
Pascal-André Vendittoli et al.
Acta orthopaedica Belgica, 79(2), 181-190 (2013-07-05)
We report the long-term results of a randomized clinical trial that compares, in total hip arthroplasty in a young population, metal-on-conventional polyethylene and alumina-on-alumina ceramic bearings. One hundred and forty hips in 116 patients were randomized. Re-operation, revision rate, clinical
M C Gornick et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 144B(3), 379-382 (2006-12-16)
Polymorphisms of the dopamine receptor D4 gene DRD4, 11p15.5, have previously been associated with attention-deficit/hyperactivity disorder (ADHD) [Bobb et al., 2005; Am J Med Genet B Neuropsychiatr Genet 132:109-125; Faraone et al., 2005; Biol Psychiatry 57:1313-1323; Thapar et al., 2005;
Michael S Oldenburg et al.
The Laryngoscope, 128(1), 160-167 (2017-09-13)
Design and test a novel biomaterial for injection laryngoplasty aimed to increase the duration of effectiveness of micronized acellular dermis. Animal model. Injection laryngoplasty was performed in three groups (n = 5) of New Zealand White rabbits. Acellular dermis was
Somnath Mandal et al.
Food chemistry, 146, 394-403 (2013-11-02)
Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour. In the present study, Lox isozymes were purified to near homogeneity (107-fold). Lox-2 and 3 displayed remarkable kinetic preference (1.7 and 1.5-fold, respectively)
Sandra S Strautnieks et al.
Gastroenterology, 134(4), 1203-1214 (2008-04-09)
Patients with severe bile salt export pump (BSEP) deficiency present as infants with progressive cholestatic liver disease. We characterized mutations of ABCB11 (encoding BSEP) in such patients and correlated genotypes with residual protein detection and risk of malignancy. Patients with
Oliver M Sieber et al.
The New England journal of medicine, 348(9), 791-799 (2003-02-28)
Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the APC gene. We screened
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