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Schlüsselwort:'serotonine'
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Valentina R Garbarino et al.
Pharmacological research, 140, 85-99 (2018-07-17)
A variety of human and animal studies support the hypothesis that serotonin (5-hydroxytryptamine or 5-HT) system dysfunction is a contributing factor to the development of autism in some patients. However, many questions remain about how developmental manipulation of various components
Luciana Romina Frick et al.
Behavioural brain research, 277, 193-203 (2014-06-21)
Serotonin (5-HT) has been proposed as a possible encoder of reward. Nevertheless, the role of this neurotransmitter in reward-based tasks is not well understood. Given that the major serotonergic circuit in the rat brain comprises the dorsal raphe nuclei and
Maria Baou et al.
Schizophrenia research, 170(1), 18-29 (2015-12-09)
Serotonin is a neurotransmitter that plays a predominant role in mood regulation. The importance of the serotonin pathway in controlling behavior and mental status is well recognized. All the serotonin elements - serotonin receptors, serotonin transporter, tryptophan hydroxylase and monoamine
Meagan A Quinlan et al.
ACS chemical neuroscience, 10(7), 3249-3260 (2019-01-23)
The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. In a study of families with multiple individuals diagnosed with autism spectrum disorder (ASD), we previously identified several, rare, missense coding
Robert Haberzettl et al.
Behavioural brain research, 277, 204-210 (2014-05-02)
In humans, the ingestion of the combination of two or more serotonin (5-HT)-enhancing drugs but also of a single drug in overdose can induce serious adverse effects, which are characteristics of the serotonin syndrome (SS). In mice, acute administration of
Marta Baranowska-Kuczko et al.
Pharmacological reports : PR, 72(3), 756-762 (2020-04-26)
LY393558 is a combined antagonist of serotonin (5-HT) 5-HT1B receptors and inhibitor of serotonin transporter (SERT). LY393558 reduces 5-HT-induced vasoconstriction and remodelling of rat and/or mouse pulmonary arteries. The aim of our study was to examine the effect of LY393558
Haley N Janowitz et al.
eNeuro, 11(2) (2024-02-15)
A current hypothesis to explain the limited recovery following brain and spinal cord trauma stems from the dogma that neurons in the mammalian central nervous system lack the ability to regenerate their axons after injury. Serotonin (5-HT) neurons in the
Alessandra Tempio et al.
International journal of molecular sciences, 21(24) (2020-12-23)
Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role in mitochondrial biogenesis in cortical
Yu Miyahara et al.
European journal of pharmacology, 883, 173319-173319 (2020-07-04)
The roles of serotonin and noradrenaline in the modulation of chronic pruriceptive processing currently remain unclear. To clarify the contribution of serotonin and noradrenaline to chronic itch, the effects of the administration of antidepressants or noradrenaline reuptake inhibitors were evaluated
Isha Singh et al.
Cell, 186(10), 2160-2175 (2023-05-04)
The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state except ibogaine, which has unusual anti-depressant and substance-withdrawal effects, and stabilizes
Cassidy Delaney et al.
American journal of physiology. Lung cellular and molecular physiology, 304(12), L894-L901 (2013-04-23)
Although past studies demonstrate that altered serotonin (5-HT) signaling is present in adults with idiopathic pulmonary arterial hypertension, whether serotonin contributes to the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN) is unknown. We hypothesized that 5-HT contributes to
Takuya Yokoyama et al.
Neuroscience letters, 597, 149-153 (2015-05-06)
In the present study, we examined serotonin (5-HT)-induced intracellular Ca(2+) ([Ca(2+)]i) responses to hypoxia in glomus cells isolated from carotid body (CB) of the rat. 5-HT did not induce any [Ca(2+)]i responses in clustered glomus cells during normoxia (21% O2)
Mostafa El Mansari et al.
Psychopharmacology, 232(13), 2343-2352 (2015-02-11)
Vortioxetine is a novel multimodal antidepressant that is a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist, an inhibitor of the serotonin (5-HT) transporter, and a 5-HT1D, 5-HT3, and 5-HT7 receptor antagonist in vitro. In vivo studies have shown that
Yuuki Ishita et al.
G3 (Bethesda, Md.), 11(2) (2021-02-19)
Feeding behavior is one of the most fundamental behaviors in animals, and regulation of this behavior is critical for proper food intake. The nematode Pristionchus pacificus exhibits dimorphism in feeding behavior, bacterial feeding and predatory feeding on other nematodes, and
Shannon R Murphy et al.
Toxicological sciences : an official journal of the Society of Toxicology, 134(1), 168-179 (2013-04-11)
Ozone, a pervasive environmental pollutant, adversely affects functional lung growth in children. Animal studies demonstrate that altered lung development is associated with modified signaling within the airway epithelial mesenchymal trophic unit, including mediators that can change nerve growth. We hypothesized
Amanda M K Madden et al.
Developmental neurobiology, 76(11), 1241-1253 (2016-02-24)
Testosterone and its metabolites masculinize the brain during a critical perinatal window, including the relative volume of sexually dimorphic brain areas such as the sexually dimorphic nucleus of the preoptic area (SDN), which is larger in males than females. Serotonin
Trine Nygaard Jørgensen et al.
Neurochemistry international, 73, 107-112 (2014-01-28)
The serotonin transporter (SERT) terminates serotonergic signaling and enables refilling of synaptic vesicles by mediating reuptake of serotonin (5-HT) released into the synaptic cleft. The molecular and cellular mechanisms controlling SERT activity and surface expression are not fully understood. Here
Carmen M Deveau et al.
Biochemical pharmacology, 183, 114349-114349 (2020-11-28)
Serotonin neurotransmission is largely governed by the regulation of the serotonin transporter (SERT). SERT is modulated in part by cholesterol, but the role of cholesterol and lipid signaling intermediates in regulating SERT are unknown. Serotonergic neurons were treated with statins
Aurélie Flaive et al.
Journal of neurophysiology, 123(6), 2326-2342 (2020-05-14)
Serotoninergic (5-HT) neurons are powerful modulators of spinal locomotor circuits. Most studies on 5-HT modulation focused on the effect of exogenous 5-HT and these studies provided key information about the cellular mechanisms involved. Less is known about the effects of
John J Tackett et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 31(3), e13498-e13498 (2018-11-06)
Knock-out of serotonin re-uptake transporters (SERT) or use of selective serotonin re-uptake inhibitors (SSRIs) potentiates enteric serotonin (5-HT) signaling and stimulates enterocyte proliferation. We hypothesized that increased serotonin signaling would mitigate epithelial injury from intestinal ischemia and reperfusion (I/R). Mice
Paulina S Rojas et al.
Journal of neuroscience research, 92(8), 1000-1009 (2014-04-23)
Serotonin (5-HT) production and expression of 5-HT receptors (5-HTRs) occur early during prenatal development. Recent evidence suggests that, in addition to its classical role as a neurotransmitter, 5-HT regulates neuronal connectivity during mammalian development by modulating cell migration and neuronal
Ronald J Trotta et al.
Journal of animal science, 101 (2023-04-03)
Ergovaline (ERV), produced in toxic endophyte-infected tall fescue, causes potent vasoconstriction of bovine peripheral and visceral vasculature. Ergovaline acts as both an agonist and an antagonist in bovine gut blood vessels through serotonin (5-HT) receptors and it appears that the
Carl L Faingold et al.
Epilepsy & behavior : E&B, 37, 198-203 (2014-07-30)
In the DBA/1 mouse model of sudden unexpected death in epilepsy (SUDEP), administration of a selective serotonin (5-HT) reuptake inhibitor (SSRI), fluvoxamine, completely suppressed seizure-induced respiratory arrest (S-IRA) at 30 min after administration (i.p.) in a dose-related manner without blocking
Jun Namkung et al.
Molecules and cells, 38(12), 1023-1028 (2015-12-03)
Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity
R Forcén et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(9), 1258-1266 (2015-06-09)
Microbiota through toll-like receptors (TLR) may regulate gastrointestinal motility by activating neuroendocrine mechanisms. We evaluated the influence of TLR2 and TLR4 in the spontaneous contractions and serotonin (5-HT)-induced motor response in mouse ileum, and the 5-HT receptors involved. Muscle contractility
Bin Wang et al.
The Journal of nutrition, 150(7), 1966-1976 (2020-05-10)
L-tryptophan (Trp) has been reported to regulate gut immune responses during inflammation. However, the underlying mechanisms are largely unknown. We investigated the role of Trp supplementation on the serotonin receptor (HTR)-mediated immune response in the colon of mice with dextran
Dipanjan Guha et al.
In vitro cellular & developmental biology. Animal, 56(7), 511-521 (2020-08-08)
Psychological stress is an important cause to induce various metabolic disorders such as obesity, type II diabetes, and cardiovascular disorders by affecting the visceral adipose tissue. Pathophysiology of these diseases is often accompanied by the hyperactive immune system. The hyperactive
Sattar Ostadhadi et al.
Fundamental & clinical pharmacology, 29(3), 310-315 (2015-02-26)
Serotonin (5-hydroxytryptamine, 5-HT) acts as a pruritogen in humans and animals, but the mechanisms of action through that serotonin induces itch response have not been extensively discovered. In our study, we attempted to investigate the role of 5-HT3 receptors in
Robert W Garvey et al.
ChemMedChem, 17(10), e202100759-e202100759 (2022-03-15)
Mounting evidence suggests that the serotonin system serves in signal transmission to regulate insulin secretion in pancreatic islets of Langerhans. Among the 5-HT receptor subtype found in pancreatic islets, serotonin receptor 1A (5-HT1A ) demonstrates a unique ability to inhibit
Eleftherios Zarkadas et al.
Structure (London, England : 1993), 28(10), 1131-1140 (2020-07-30)
Inaccurately perceived as niche drugs, antiemetics are key elements of cancer treatment alleviating the most dreaded side effect of chemotherapy. Serotonin 5-HT3 receptor antagonists are the most commonly prescribed class of drugs to control chemotherapy-induced nausea and vomiting. These antagonists
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