Merck
  • L020000HH
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L020000-HH

Sigma-Aldrich

TCA Deblock

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NACRES:
NA.21

type

for DNA synthesis

Quality Level

200

product line

Proligo Reagents

packaging

pkg of 4 × 2.5 L (L020250-04)
pkg of 1 × 25 L (L022500-01)
pkg of 4 × 4 L (L020400-04)

concentration

28-32 g/L (TCA content, titration)

impurities

≤200 ppm water content (Karl Fischer)

color

clear

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Preparation Note

Trichloroacetic acid / Dichloromethane 3/100 (v/v)

Other Notes

Deblock solution containing trichloroacetic acid (TCA) in dichloromethane removes the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 2 - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

212.0 °F - closed cup

Flash Point(C)

100 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificate of Analysis

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Certificate of Origin

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