Merck
  • L040150
All Photos(1)

L040150

Sigma-Aldrich

Cap 1

All Photos(1)
Synonym(s):
Cap A
NACRES:
NA.21

type

for DNA synthesis

Quality Level

200

product line

Proligo Reagents

storage condition

dry at room temperature

impurities

≤200 ppm water content (Karl Fischer)

color

clear

suitability

conforms to structure (GC, Formulation)

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1 of 4

This Item
L040080L040030L040031
Sigma-Aldrich

Sigma-Aldrich

L040150

Cap 1

Sigma-Aldrich

Sigma-Aldrich

L040080

Cap A

Sigma-Aldrich

Sigma-Aldrich

L040030

Cap A

Sigma-Aldrich

Sigma-Aldrich

L040031

Cap A

type

for DNA synthesis

type

for DNA synthesis

type

for DNA synthesis

type

for DNA synthesis

product line

Proligo Reagents

product line

Proligo Reagents

product line

Proligo Reagents

product line

Proligo Reagents

storage condition

dry at room temperature

storage condition

dry at room temperature

storage condition

-

storage condition

-

impurities

≤200 ppm water content (Karl Fischer)

impurities

-

impurities

-

impurities

-

color

clear

color

clear

color

clear colorless, to brownish

color

clear colorlessto brownish

suitability

conforms to structure (GC, Formulation)

suitability

-

suitability

-

suitability

-

General description

Cap 1 solution consists of n-methylimidazole, lutidine, and acetonitrile (ACN).

Application

Cap 1 is suitable for use after the phosphoramidite reaction/coupling step.

Biochem/physiol Actions

Cap 1 solution aborts chains bearing unreacted 5′hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps.

Preparation Note

Acetonitrile / Lutidine / N-Methylimidazole 8/1/1 (v/v/v)

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

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