Merck

1.00162

SAFC

Boric acid

powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

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Synonym(s):
Orthoboric acid, Trihydroxidoboron
Linear Formula:
H3BO3
CAS Number:
Molecular Weight:
61.83
MDL number:
EC Index Number:
233-139-2

Agency

BP
JP
NF
Ph. Eur.

Quality Level

vapor pressure

2.6 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

99.5-100.5% dry basis (alkalimetric)

form

powder
solid

pH

3.8-4.8 (20 °C, 33 g/L in H2O)

mp

160 °C (dec.) (lit.)

solubility

49.2 g/L

density

1.489 g/cm3 at 23 °C

anion traces

sulfate (SO42-): ≤0.04%

cation traces

As: ≤0.0001%
heavy metals (as Pb): ≤0.0015%

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OB(O)O

InChI

1S/BH3O3/c2-1(3)4/h2-4H

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

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This Item
1076341PHR2664NIST973
Boric acid powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

1.00162

Boric acid

Boric acid United States Pharmacopeia (USP) Reference Standard

1076341

Boric acid

Boric acid pharmaceutical secondary standard, certified reference material

PHR2664

Boric acid

Boric acid NIST® SRM® 973, acidimetric standard

NIST973

Boric acid

agency

BP, NF, JP, Ph. Eur.

agency

-

agency

traceable to NIST NIST951A, traceable to NIST NIST973, traceable to USP 1076341

agency

-

Quality Level

500

Quality Level

-

Quality Level

300

Quality Level

100

form

powder, solid

form

solid

form

powder

form

-

storage temp.

2-30°C

storage temp.

-

storage temp.

2-30°C

storage temp.

-

solubility

49.2 g/L

solubility

boiling water: freely soluble, ethanol: soluble, glycerol: freely soluble

solubility

-

solubility

-

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid has antimicrobial characteristics and is therefore typically used as preservative in pharmaceutical formulations and cosmetics. It is also used as buffering agent and pH adjuster.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

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25G
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