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Merck

1.00162

Boric acid

powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF, ChP

Synonym(s):

Orthoboric acid, Trihydroxidoboron

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About This Item

Linear Formula:
H3BO3
CAS Number:
Molecular Weight:
61.83
MDL number:
UNSPSC Code:
12352301
EC Index Number:
233-139-2

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Agency

BP
ChP
JP
NF
Ph. Eur.

Quality Level

vapor pressure

2.6 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

99.5-100.5% dry basis (alkalimetric)

form

powder
solid

pH

3.8-4.8 (20 °C, 33 g/L in H2O)

mp

160 °C (dec.) (lit.)

solubility

49.2 g/L

density

1.489 g/cm3 at 23 °C

anion traces

sulfate (SO42-): ≤0.04%

cation traces

As: ≤0.0001%
heavy metals (as Pb): ≤0.0015%

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OB(O)O

InChI

1S/BH3O3/c2-1(3)4/h2-4H

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

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This Item
1.00160107634131146
application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

application(s)

pharmaceutical (small molecule)

application(s)

-

agency

BP, NF, JP, Ph. Eur.

agency

BP, JP, NF, Ph. Eur.

agency

-

agency

USP/NF, reag. ISO, reag. Ph. Eur.

form

powder, solid

form

crystalline, solid

form

solid

form

powder or crystals

assay

99.5-100.5% dry basis (alkalimetric)

assay

99.5-100.5% dry basis (alkalimetric)

assay

-

assay

≥99.8%

product line

EMPROVE® ESSENTIAL

product line

EMPROVE® ESSENTIAL

product line

-

product line

-

solubility

49.2 g/L

solubility

49.2 g/L

solubility

boiling water: freely soluble, ethanol: soluble, glycerol: freely soluble

solubility

water: soluble

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid has antimicrobial characteristics and is therefore typically used as preservative in pharmaceutical formulations and cosmetics. It is also used as buffering agent and pH adjuster.

Preparation Note

Must be subjected to further processing during the preparation of injectable dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

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Articles

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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