1.00662

Sorbic acid

EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, NF, FCC, E 200

• Synonym(s): Sorbic acid, 2,4-Hexadienic acid
• Empirical Formula (Hill Notation): C₆H₈O₂
• CAS Number: 110-44-1
• Molecular Weight: 112.13
• UNSPSC Code: 12352106
• E Number: E200
• EC Index Number: 203-768-7
• MDL number: MFCD00002703

Properties

• Quality Segment: 500
• agency: BP, ChP, NF, Ph. Eur.
• reg. compliance: FCC
• vapor pressure: 0.00018 hPa ( 20 °C)
• product line: EMPROVE^® ESSENTIAL
• assay: 99.0-101.0% substance (anhydrous) basis (acidimetric)
• form: solid
• autoignition temp.: >130 °C
• technique(s): API processing | cocrystal formation: suitable, API processing | salt formation: suitable
• pH: 3.3 (20 °C, 1.6 g/L in H₂O)
• bp: 160-260 °C/1013 hPa (decomposition)
• mp: 120-150 °C
• solubility: 1.6 g/L
• density: 1.2 g/cm³ at 20 °C
• cation traces: As: ≤0.0003%, Cd: ≤0.001%, Cu: ≤0.001%, Hg: ≤0.0001%, Pb: ≤0.0002%, Zn: ≤0.001%, heavy metals (as Pb): ≤0.0010%
• application(s): liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 15-25°C
• SMILES string: OC(=O)\C=C\C=C\C
• InChI: 1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+
• InChI key: WSWCOQWTEOXDQX-MQQKCMAXSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sorbic acid is commonly used as a preservative in pharmaceutical formulations and cosmetics. It is also used as additive for the preservation of food.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to the US EPA′s Federal Insecticide Fungicide and Rodenticide Act, the European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR), and others.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• flash_point_f: 260.6 °F - closed cup
• flash_point_c: 127 °C - closed cup