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PHR1006

Supelco

Sorbitol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
D-Sorbitol, D-Glucitol
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721899
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. S100000
traceable to USP 1617000

vapor density

<1 (vs air)

vapor pressure

<0.1 mmHg ( 25 °C)

API family

sorbitol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

98-100 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-JGWLITMVSA-N

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1 of 4

This Item
S1000000161700056755-M
Sorbitol Pharmaceutical Secondary Standard; Certified Reference Material

PHR1006

Sorbitol

Sorbitol European Pharmacopoeia (EP) Reference Standard

S1000000

Sorbitol

Sorbitol United States Pharmacopeia (USP) Reference Standard

1617000

Sorbitol

Sorbitol A sugar alcohol produced by reduction of glucose.

56755-M

Sorbitol

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

format

neat

format

neat

format

neat

format

-

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

100

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

10-30°C

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Application

Sorbitol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography technique.
Sorbitol may be used as an internal standard in the quantitative determination ofD-glucose in corn sugar and corn syrups using gas liquid chromatography (GLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7795 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Sigma-Aldrich

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D-Sorbitol

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Sigma-Aldrich

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Sigma-Aldrich

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SAFC

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D(-)-Sorbitol

Dextrose Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1000

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Use of sorbitol as internal standard in determination of D-glucose by gas liquid chromatography
Alexander.J.R and Garbutt.T.J
Analytical Chemistry, 37, 303-305 (1965)
An isocratic HPLC method for the determination of sorbitol and glycerol in pharmaceutical formulations
Simonzadeh N and Ronsen B
Journal of Chromatographic Science, 50(7), 644-647 (2012)
Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
Youngkook Kwon et al.
ChemSusChem, 6(3), 455-462 (2013-01-25)
This Full Paper addresses the electrocatalytic hydrogenation of glucose to sorbitol or 2-deoxysorbitol on solid metal electrodes in neutral media. Combining voltammetry and online product analysis with high-performance liquid chromatography (HPLC), provides both qualitative and quantitative information regarding the reaction
Anna Boccaccio et al.
Cellular and molecular life sciences : CMLS, 71(21), 4275-4283 (2014-04-29)
Two-pore channel proteins (TPC) encode intracellular ion channels in both animals and plants. In mammalian cells, the two isoforms (TPC1 and TPC2) localize to the endo-lysosomal compartment, whereas the plant TPC1 protein is targeted to the membrane surrounding the large

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