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PHR1346

Supelco

Methylsulfonylmethane

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Dimethyl sulfone, Methyl sulfone
Linear Formula:
(CH3)2SO2
CAS Number:
Molecular Weight:
94.13
Beilstein:
1737717
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1437600

API family

methylsulfonylmethane

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

238 °C (lit.)

mp

107-109 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CS(C)(=O)=O

InChI

1S/C2H6O2S/c1-5(2,3)4/h1-2H3

InChI key

HHVIBTZHLRERCL-UHFFFAOYSA-N

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This Item
41867D8418PHR1464
Methylsulfonylmethane Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1346

Methylsulfonylmethane

Dimethyl sulfone Standard for quantitative NMR, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

41867

Dimethyl sulfone

Dimethyl sulfoxide for molecular biology

Sigma-Aldrich

D8418

Dimethyl sulfoxide

Dapsone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1464

Dapsone

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable, qNMR: suitable

technique(s)

DNA sequencing: suitable, PCR: suitable, transfection: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
environmental
flavors and fragrances
food and beverages
personal care
pharmaceutical

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

storage temp.

2-30°C

storage temp.

-

storage temp.

room temp

storage temp.

2-30°C

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

300

General description

Methylsulfonylmethane is the oxidized form of dimethyl sulfoxide, generally occurring in green plants, fruits and vegetables. Methylsulfonylmethane can find applications as a solvent to dissolve a wide range of solutes and is also generally used for high temperature reactions. It exhibits pharmacological properties and is reported to reduce peripheral pain, inflammation and arthritis condition.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3469 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee
Brien S, et al.
Evidence-Based Complementary and Alternative Medicine (2011)
Methylsulfonylmethane (MSM). Monograph.
Alternative medicine review : a journal of clinical therapeutic, 8(4), 438-441 (2003-12-05)
Jacob F Smith et al.
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Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative
S Brien et al.
Osteoarthritis and cartilage, 16(11), 1277-1288 (2008-04-18)
Conventional treatment of osteoarthritis (OA) with non-steroidal anti-inflammatory drugs is associated with serious gastrointestinal side effects and in view of the recent withdrawal of some cyclo-oxygenase-2 inhibitors, identifying safer alternative treatment options is needed. The objective of this systematic review
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