Documents
A211050
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
configured for (ÄKTA® and OligoPilot®)
Recommended Products
biological source
non-animal source (no BSE/TSE risk)
Quality Level
product line
Proligo Reagents
Assay
≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)
form
powder
technique(s)
oligo synthesis: suitable
impurities
≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤0.5% single Impurity (reversed phase HPLC)
≤3% residual Solvent content
color
white to off-white
λ
conforms (UV/VIS Identity)
suitability
conforms to structure for H-NMR
conforms to structure for LC-MS
compatibility
configured for (ÄKTA® and OligoPilot®)
nucleoside profile
base: adenosine
base protecting group: benzoyl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: standard
storage temp.
−20°C
SMILES string
COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
InChI
1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
InChI key
FFXHNCNNHASXCT-RFMFGJHUSA-N
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Related Categories
1 of 4
This Item | A211030 | A211040 | A211000 |
|---|---|---|---|
| assay ≥99% (31P-NMR), ≥99.0% (reversed phase HPLC) | assay ≥99% (31P-NMR), ≥99.0% (reversed phase HPLC) | assay ≥99% (31P-NMR), ≥99.0% (reversed phase HPLC) | assay ≥99% (31P-NMR), ≥99.0% (reversed phase HPLC) |
| form powder | form powder | form powder | form powder |
| impurities ≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content | impurities ≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content | impurities ≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content | impurities ≤0.3 wt. % water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3 wt. % residual Solvent content |
| color white to off-white | color white to off-white | color white to off-white | color white to off-white |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
General description
Key Features
- Industry-standard 2′O-TBDMS protective group
- Consistent lot-to-lot purity and performance
- Compatible with deprotection methods based on methylamine or AMA
- Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with activator 42
- Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
- Manufactured under a certified ISO 9001 quality system
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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