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C3025

Sigma-Aldrich

(±)-Chlorpheniramine maleate salt

≥99% (perchloric acid titration)

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Empirical Formula (Hill Notation):
C16H19ClN2 · C4H4O4
CAS Number:
Molecular Weight:
390.86
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥99% (perchloric acid titration)

form

powder

mp

130-135 °C (lit.)

originator

Bayer

SMILES string

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DBAKFASWICGISY-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

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1 of 4

This Item
C4915P5514P6902
(±)-Chlorpheniramine maleate salt ≥99% (perchloric acid titration)

C3025

(±)-Chlorpheniramine maleate salt

S-(+)-Chlorpheniramine maleate salt

C4915

S-(+)-Chlorpheniramine maleate salt

Pyrilamine maleate salt

P5514

Pyrilamine maleate salt

Pheniramine maleate salt

P6902

Pheniramine maleate salt

assay

≥99% (perchloric acid titration)

assay

-

assay

-

assay

-

originator

Bayer

originator

Bayer

originator

Watson

originator

-

mp

130-135 °C (lit.)

mp

-

mp

-

mp

-

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

General description

Chlorpheniramine maleate (CPM)/(3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine is an alkylamine antihistamine.

Application

(±)-Chlorpheniramine maleate salt has been used:
  • as H1 receptor antagonist to determine the receptor function
  • to block the effect of compound 48/80 on plasma IGF-I
  • as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Biochem/physiol Actions

Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.
H1 Histamine receptor antagonist.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Functionalized Fe3O4 Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl
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Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat
Liao W, et al.
European Journal of Pharmacology, 374(3), 471-476 (1999)
Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer
Saleh TA
Journal of Pharmaceutical Analysis, 1(4), 246-250 (2011)
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V Alagarsamy et al.
European journal of medicinal chemistry, 43(11), 2331-2337 (2007-11-23)
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