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Debrisoquine sulfate

Name: Debrisoquine sulfate
Brand: SIGMA

powder, ≥98% (TLC)

Synonym(s):

3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, Debrisoquin sulfate, Ro 5-33071

About This Item

Linear Formula:

C₂₀H₂₆N₆ · H₂SO₄

CAS Number:

581-88-4

Molecular Weight:

448.54

NACRES:

NA.32

PubChem Substance ID:

24277710

UNSPSC Code:

12352204

EC Number:

209-472-4

MDL number:

MFCD00153791

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Properties

Product Name

Debrisoquine sulfate,

assay

≥98% (TLC)

Quality Level

200

form

powder

mp

285 °C

solubility

H₂O: 20 mg/mL (with heat)

storage temp.

room temp

SMILES string

OS(O)(=O)=O.NC(=N)N1CCc2ccccc2C1.NC(=N)N3CCc4ccccc4C3

InChI

1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)

InChI key

CAYGYVYWRIHZCQ-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530)

Description

General description

A substrate for cytochrome P450 CYP2D6;[1][2] an indicator for genetic polymorphism in cytochrome P450.[3]

Biochem/physiol Actions

Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.

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Show Differences

1 of 1

This Item	UC261	SML0140	N0165
Sigma-Aldrich D1306 Debrisoquine sulfate	Sigma-Aldrich UC261 (±)-4-Hydroxydebrisoquin sulfate	Sigma-Aldrich SML0140 BV02	Sigma-Aldrich N0165 Nisoldipine
assay ≥98% (TLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Gene Information human ... SLC6A2(6530)	Gene Information -	Gene Information -	Gene Information human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
form powder	form solid	form powder	form powder
solubility H₂O: 20 mg/mL (with heat)	solubility -	solubility DMSO: >5 mg/mL	solubility DMSO: >10 mg/mL
storage temp. room temp	storage temp. 2-8°C	storage temp. room temp	storage temp. room temp

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Phase I Drug Metabolism

Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.

The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype.

N E Caporaso et al.

Environmental health perspectives, 98, 101-105 (1992-11-01)

Debrisoquine is an antihypertensive drug that is metabolized by cytochrome P4502D6. Deficient metabolism is inherited as an autosomal recessive condition. We previously reported in a case-control study that extensive metabolizers of debrisoquine were at greater risk of lung cancer compared

Cytochrome P450IID subfamily in non-human primates. Catalytical and immunological characterization.

E Jacqz-Aigrain et al.

Biochemical pharmacology, 41(11), 1657-1663 (1991-06-01)

Interindividual variations of debrisoquine metabolism was recently identified in non-human primates tested in vivo. The catalytical and immunological characterization of cytochrome P450IID subfamily was undertaken in hepatic microsomes from extensive metabolizer primates. The NADPH/O2 mediated metabolism of debrisoquine, dextromethorphan and

Metabolomic profiles of current cigarette smokers.

Ping-Ching Hsu et al.

Molecular carcinogenesis, 56(2), 594-606 (2016-06-25)

Smoking-related biomarkers for lung cancer and other diseases are needed to enhance early detection strategies and to provide a science base for tobacco product regulation. An untargeted metabolomics approach by ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF MS) totaling

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Global Trade Item Number

SKU	GTIN
D1306-100MG	04061833559345

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