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G111000

Sigma-Aldrich

DMT-dG(ib) Phosphoramidite

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Synonym(s):
DMT-dG(ib) amidite, Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
Empirical Formula (Hill Notation):
C44H54N7O8P
CAS Number:
Molecular Weight:
839.92
MDL number:
PubChem Substance ID:
NACRES:
NA.51

biological source

non-animal source (no BSE/TSE risk)

Quality Level

type

for DNA synthesis

product line

Proligo Reagents

Assay

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

≤0.3 wt. % water content (Karl Fischer)

color

white to off-white

λ

conforms (UV/VIS Identity)

nucleoside profile

base: deoxyguanosine
base protecting group: isobutyryl
2' protecting group: none
5' protecting group: DMT
deprotection: standard

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6

InChI

1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1

InChI key

FDRMKYVTIFSDPR-MMROLVBFSA-N

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This Item
G111040G111050G111080
DMT-dG(ib) Phosphoramidite

G111000

DMT-dG(ib) Phosphoramidite

DMT-dG(ib) Phosphoramidite configured for MerMade

G111040

DMT-dG(ib) Phosphoramidite

DMT-dG(ib) Phosphoramidite configured for ABI, configured for (ÄKTA® and OligoPilot®)

G111050

DMT-dG(ib) Phosphoramidite

DMT-dG(ib) Phosphoramidite configured for PerkinElmer, configured for Polygen

G111080

DMT-dG(ib) Phosphoramidite

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

color

white to off-white

color

white to off-white

color

white to off-white

color

white to off-white

impurities

≤0.3 wt. % water content (Karl Fischer)

impurities

≤0.3 wt. % water content (Karl Fischer)

impurities

≤0.3 wt. % water content (Karl Fischer)

impurities

≤0.3 wt. % water content (Karl Fischer)

General description

DMT-dG(ib) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:

  • Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
  • Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides
  • The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides

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