Merck
  • G211030
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G211030

Sigma-Aldrich

DMT-2′O-TBDMS-rG(ib) Phosphoramidite

configured for ABI

Synonym(s):
N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-guanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Empirical Formula (Hill Notation):
C50H68N7O9PSi
CAS Number:
Molecular Weight:
970.18
MDL number:
PubChem Substance ID:

biological source

non-animal source (no BSE/TSE risk)

Quality Level

product line

Proligo Reagents

Assay

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

form

powder

technique(s)

oligo synthesis: suitable

impurities

≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤0.5% single Impurity (reversed phase HPLC)
≤3% residual Solvent content

color

white to off-white

λ

conforms (UV/VIS Identity)

suitability

conforms to structure for H-NMR
conforms to structure for LC-MS

compatibility

configured for ABI

nucleoside profile

base: guanosine
base protecting group: isobutyryl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: standard

storage temp.

−20°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6

InChI

1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(66-68(12,13)49(7,8)9)42(65-67(63-29-17-28-51)57(33(3)4)34(5)6)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m1/s1

Inchi Key

PGJKESPHANLWME-FTZVBZPOSA-N

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This Item
A214630C213030G211630
biological source

non-animal source (no BSE/TSE risk)

biological source

-

biological source

non-animal source (no BSE/TSE risk)

biological source

-

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥98% (31P-NMR), ≥98.0% (reversed phase HPLC)

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

assay

≥98% (31P-NMR), ≥98.0% (reversed phase HPLC)

form

powder

form

-

form

powder

form

solid

impurities

≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content

impurities

≤-0.5% 31P-NMR P(III) impurites 145-155ppm (31P-NMR), ≤-0.5% Impurity 3′-TC Isomer (reversed phase HPLC)

impurities

≤0.3% water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3% residual Solvent content

impurities

≤0.3 wt. % water content (Karl Fischer), ≤0.5% 3′-TC isomer (reversed phase HPLC), ≤0.5% P(III) Impurities 145-155ppm (31P-NMR)

color

white to off-white

color

-

color

white to off-white

color

white to light yellow

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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