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P6500
Pentylenetetrazole
≥99% (GC), powder, CNS stimulant
Synonym(s):
α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole
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25 G
€67.90
50 G
€120.00
100 G
€216.00
About This Item
Empirical Formula (Hill Notation):
C6H10N4
CAS Number:
Molecular Weight:
138.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-219-3
MDL number:
Form:
powder
Quality level:
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Product Name
Pentylenetetrazole,
InChI key
CWRVKFFCRWGWCS-UHFFFAOYSA-N
InChI
1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
SMILES string
C1CCc2nnnn2CC1
form
powder
bp
194 °C/12 mmHg (lit.)
mp
59-61 °C (lit.)
storage temp.
−20°C
Quality Level
Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| form powder | form powder | form liquid | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. - |
| bp 194 °C/12 mmHg (lit.) | bp - | bp - | bp - |
| mp 59-61 °C (lit.) | mp - | mp - | mp - |
General description
Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures.[1] It can traverse the blood-brain barrier.
Application
Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.
Biochem/physiol Actions
Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Ervand G Paronikyan et al.
MedChemComm, 10(8), 1399-1411 (2019-09-20)
8-Hydrazino derivatives of pyrano[3,4-c]pyridines and derivatives of the new heterocyclic system 3-thioxopyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines on the basis of methanesulfonates of pyrano[3,4-c]pyridinium were synthesized by optimization of a previously used method. Derivatives of alkylsulfonyl pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines were also synthesized. All compounds were evaluated for
Tatiana Afrikanova et al.
PloS one, 8(1), e54166-e54166 (2013-01-24)
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of
Rufi Tambe et al.
Pharmaceutical biology, 55(1), 264-268 (2016-12-09)
Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically
Effects of bee products on pentylenetetrazole-induced seizures in the rat
Zarraga-Galindo N, et al.
Proceedings of the Western Pharmacology Society, 54, 33-40 (2011)
Perineuronal net degradation in epilepsy
Rankin-Gee EK, et al.
Epilepsia, 56(7), 1124-1133 (2015)
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What is the Department of Transportation shipping information for this product?
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How do I solubilize Product P6500, Pentylenetetrazole?
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We test the solubility of this compound at a concentration of 50 mg/mL in water.
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What is the solution stability for Product P6500, Pentylenetetrazole?
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We do not have any solution stability information for this product. It is always best to make a fresh solution. If this is not possible, you can try storing solution in single use aliquots at -20°C.
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Can Product P6500, Pentylenetetrazole, be used to induce convulsions?
1 answer-
Pentylenetetrazole induced convulsions have been reported by De Sarro G. et al., in Eur. J. Pharmacol., 368(2-3),149-159 (1999).
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