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Membrane dynamics and protein targets of lipid droplet microautophagy during ER stress-induced proteostasis in the budding yeast, Saccharomyces cerevisiae.

Enrique J Garcia et al.

Autophagy, 17(9), 2363-2383 (2020-10-07)

Our previous studies reveal a mechanism for lipid droplet (LD)-mediated proteostasis in the endoplasmic reticulum (ER) whereby unfolded proteins that accumulate in the ER in response to lipid imbalance-induced ER stress are removed by LDs and degraded by microlipophagy (µLP)

Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.

Louise A Knight et al.

BMC cancer, 9, 38-38 (2009-01-30)

Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients. We have examined the effect of fluvastatin alone and in

The Role of Mesenchymal Stem Cells with Ascorbic Acid and N-Acetylcysteine on TNF-α, IL 1β, and NF-κβ Expressions in Acute Pancreatitis in Albino Rats.

Dalia Abdelhafez et al.

Journal of diabetes research, 2021, 6229460-6229460 (2021-10-27)

Severe acute pancreatitis (SAP) is a necrotic pancreatic inflammation associated with high mortality rate (up to 70%). Bone marrow (BM) mesenchymal stem cells (MSCs) have been investigated in pancreatic cellular regeneration, but still their effects are controversial. Therefore, the present

Effect of bone marrow derived mesenchymal stem cells on healing of induced full-thickness skin wounds in albino rat.

Basiouny HS, et al.

International journal of stem cells, 6(1), 12-25 (2013)

Lineage conversion of mouse fibroblasts to pancreatic α-cells.

Tianjin Liu et al.

Experimental & molecular medicine, 49(6), e350-e350 (2017-07-01)

α-cells, which synthesize glucagon, also support β-cell survival and have the capacity to transdifferentiate into β-cells. However, the role of α-cells in pathological conditions and their putative clinical applications remain elusive due in large part to the lack of mature

MRI assessment of ischemic liver after intraportal islet transplantation.

Naoaki Sakata et al.

Transplantation, 87(6), 825-830 (2009-03-21)

There is a recent focus on embolization of the portal vein by transplanted islets as a major cause of early graft loss. The resultant ischemia causes necrosis or apoptosis of cells within the liver. Thus, noninvasive assessment of the liver

Effect of bone marrow versus adipose tissue derived mesenchymal stem cells on the pancreas of streptozotocin-induced diabetes mellitus type I in adult male rats (Histological Study)

Omar AI, et al.

The Egyptian journal of histology., 40(1), 12-24 (2017)

Isolation of centrosomes from cultured Mammalian cells

Meigs TE and Kaplan DD

Cold Spring Harbor Protocols, 2008(8), pdb-prot5039 (2008)

Interplay of Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection.

Jyoti Pant et al.

PLoS pathogens, 17(9), e1008768-e1008768 (2021-09-25)

Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective effects of TLF have been extensively investigated in the context of

Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue.

Yongtae Kim et al.

PloS one, 6(1), e14624-e14624 (2011-02-10)

Embryonic development is guided by a complex and integrated set of stimuli that results in collective system-wide organization that is both time and space regulated. These regulatory interactions result in the emergence of highly functional units, which are correlated to

A role for phosphatidic acid in the formation of "supersized" lipid droplets.

Weihua Fei et al.

PLoS genetics, 7(7), e1002201-e1002201 (2011-08-11)

Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipids. Little is known about how the size of LDs is controlled, although LDs of diverse sizes have been observed in different tissues and under different

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