GC Analysis of Water in Ibuprofen (Spiked) on Watercol™ 1910
Materials
related product
CONDITIONS
column
Watercol 1910, 30 m x 0.25 mm I.D., 0.20 μm (29711-U)
oven
35 °C (4 min), 8 °C/min to 130 °C (1 min)
inj. temp.
250 °C
detector
TCD, 200 °
carrier gas
helium, 11.40 psi constant pressure (equal to 25 cm/sec), measured with oven at 35 °C
injection
1 μL, 100:1 split
liner
4 mm I.D., split/splitless type, wool packed single taper FocusLiner™ design (2879925-U)
sample
0.198 g ibuprofen weighed into a 1 mL volumetric flask, 0.5 mL acetone added, vortexed slowly for 30 seconds, acetone added to the 1 mL line, vortexed, transferred to an autosampler vial
Description
Analysis Note
Residual moisture in an active pharmaceutical ingredient (API) is undesirable. This is because it dilutes the amount of the API. It may also interfere with the performance of the API.
The "Watercol" series of ionic liquid capillary GC columns are characterized by their ability to produce a sharp peak shape for water, sharp enough so that water can be integrated and quantified. This application shows the suitability of Watercol 1910 for the analysis of water in ibuprofen. The water peak was confirmed by injecting a series of standards (water in acetone).
Legal Information
FocusLiner is a trademark of SGE Analytical Science Pty Ltd.
Watercol is a trademark of Sigma-Aldrich Co. LLC