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HomeWebinarsIntegration of On-line HPLC as a PAT Tool for CQA Monitoring and Control in Bioprocessing

Integration of On-line HPLC as a PAT Tool for CQA Monitoring and Control in Bioprocessing



WEBINAR

High-performance liquid chromatography (HPLC) is a proven tool for the analysis of critical process parameters (CPP) and critical quality attributes (CQA) of biotherapeutics. Historically, HPLC has been performed off-line – a process that can take days or weeks to complete. By moving HPLC to the manufacturing floor as an on-line Process Analytical Technology (PAT) tool, relevant data can be accessed in a matter of minutes. In this webinar, we highlight an initial use case, demonstrating the utility of on-line HPLC to monitor and control antibody aggregation levels in bioprocessing. The implementation of PAT enables continuous manufacturing and empowers industry progress towards Bioprocessing 4.0.

In this webinar, you will learn:

  • How Process Analytical Technology (PAT) tools can facilitate progress towards Biopharma 4.0 and real-time release
  • How on-line HPLC can be implemented in a bioprocessing environment
  • The application of on-line HPLC to monitor and control critical quality attributes in bioprocessing

Speakers

Stacy Shollenberger

Stacy Shollenberger

Merck

Senior Marketing Manager, Process Analytical Technologies

Stacy Shollenberger holds an MS degree in Biochemistry from the University of Virginia and an MBA from Penn State University. She has more than 12 years of experience in analytical and bioanalytical product and method development. Currently, Stacy is a senior manager of process analytical technologies (PAT) at Merck and is responsible for defining the PAT strategy to move testing from traditional off-line quality control (QC) to QC on the bioprocessing floor.

Daniel Kutscher, Ph.D.

Daniel Kutscher, Ph.D.

Agilent Technologies

Product Manager, Strategic Marketing

Dr. Daniel Kutscher is a biochemist and experienced life-science professional with global responsibilities as a product manager for analytical HPLC. Daniel received his Ph.D. in 2011 from Justus-Liebig-University in Giessen, Germany, under the supervision of Prof. Dr. Alfred Pingoud. After completing his Ph.D., he moved to New York City, USA, and worked until 2018 as an HPLC product specialist, supporting customers in various industries. Daniel currently works for Agilent Technologies as a product manager - strategic marketing with a strong focus on better connecting the analytical with the (bio-) process world.

Webinar Information

Pharma and biopharma manufacturing

  • Downstream Processing
  • Duration:1h

  • Language:English

  • Session 1:presented November 17, 2022

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