Intensified and Continuous Upstream (USP) Processing

Future-proof your manufacturing strategies, reduce costs and increase facility flexibility with intensified fed-batch and perfusion processes

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Make the best decisions to increase productivity, reduce costs, improve facility flexibility, and future-proof manufacturing strategies by intensifying your upstream process.

Biopharmaceutical developers and manufacturers need efficient, productive upstream processes that deliver high-quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification, including intensified fed-batch and perfusion processes, offers many options to future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.

With a full suite of solutions designed to support the increased demands of intensified upstream processes and technical support from teams with years of experience, we can support you in choosing the best strategies to realize the benefits of upstream process intensification without compromising clinical milestones or speed to market.

Intensified and Continuous Upstream (USP) Processing

Today’s biopharmaceutical manufacturers are confronted with numerous challenges:

  • Speed-to-market and cost-efficient production for competitive advantage 
  • Flexibility to increase throughput or target a smaller patient population 
  • Agility to process multiple products in a single facility 
  • High volumetric productivity  with a smaller facility footprint

Upstream process intensification, as a cornerstone of this transformation, can deliver new gains in efficiency while sustaining or improving product quality. Innovative approaches are needed to address these challenges and future-proof manufacturing strategies for the facility of the future. We have developed several upstream intensification strategies for seed train and production and harvest processes, including high cell density cryopreservation and perfusion solutions. Whether you’re developing an intensified fed-batch or perfusion process, our integrated solutions enable you to increase volumetric productivity which can translate into higher throughput, improved facility utilization and flexibility, compressed timelines, and reduced manufacturing and capital costs. With technical support from a global team with extensive application and regulatory expertise we empower you to take the right decisions faster.

Connect with our experts to evaluate how we can help you make the right decisions for upstream intensification.

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