Once Fluorescein isothiocyanate-dextran (item 46944) is in solution, it is recommended to store it at -20ºC and utilize it within 3 months to maintain its potency. To prevent multiple freeze/thaw cycles, it is advisable to aliquot the solution.
46944
Fluorescein isothiocyanate–dextran
average mol wt 4,000, (FITC:Glucose = 1:250)
Synonym(s):
FITC-Dextran 4, FITC–Dextran
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1.250,00 kr.
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3.000,00 kr.
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100 MG
1.250,00 kr.
500 MG
3.000,00 kr.
About This Item
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mol wt
average mol wt 4,000
composition
(FITC:Glucose = 1:250)
extent of labeling
~0.004 mol/mol FITC glucose
solubility
H2O: 50 mg/mL, slightly hazy, orange
storage temp.
2-8°C
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This Item | FD2000S | FD40S | FD40 |
|---|---|---|---|
| solubility H2O: 50 mg/mL, slightly hazy, orange | solubility H2O: soluble 25 mg/mL | solubility H2O: soluble 25 mg/mL, clear to slightly hazy, yellow to deep orange | solubility H2O: 25 mg/mL |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mol wt average mol wt 4,000 | mol wt average mol wt 2,000,000 | mol wt average mol wt 40,000 | mol wt average mol wt 40,000 |
| composition (FITC:Glucose = 1:250) | composition - | composition - | composition - |
| extent of labeling ~0.004 mol/mol FITC glucose | extent of labeling 0.003-0.020 mol FITC per mol glucose | extent of labeling 0.003-0.020 mol FITC per mol glucose | extent of labeling 0.001-0.020 mol FITC per mol glucose |
Application
Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. FITC-dextran has been used to study plant cell wall porosity and capillary permeability. Plasma proteins have been shown not to bind to FITC-dextran.
FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination
Fluorescein isothiocyanate–dextran (FITC-Dextran 4) is use as a fluorescent probe to study cell permeability. FITC-Dextran 4 is used with to study permeability of epithelial cell such as intestinal and renal cells in vivo.
FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination
Fluorescein isothiocyanate–dextran (FITC-Dextran 4) is use as a fluorescent probe to study cell permeability. FITC-Dextran 4 is used with to study permeability of epithelial cell such as intestinal and renal cells in vivo.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What is the recommended storage method for stock solutions of item 46944, Fluorescein isothiocyanate-dextran?
1 answer-
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At what excitation and emission wavelengths should Product No. 46944, Fluorescein isothiocyanate-dextran, be read?
1 answer-
The excitation maximum for FITC-dextran is 490 nm, while the emission maximum is 520 nm.
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Are there any fluorescent hydrophobic substitutes of similar size to FITC dextran (4,000 amu) available, considering regular dextran lacks fluorescence and is hydrophilic?
1 answer-
There is only one dextran conjugated with a hydrophobic fluorescent dye. The TRITC dextran, T4037, has an average dextran weight of 4,400 amu and TRITC is slightly more hydrophobic than FITC.
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After reconstitution, how can we sterilise the dextran solution?
1 answer-
The FITC-Dextran solution can be sterilized by filtration.
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What is the stability of FITC-dextran in vivo?
1 answer-
These products are not tested on animals. Reports suggest a 24-hour in vivo stability.
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