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A6150
α1-Antitrypsin from human plasma
salt-free, lyophilized powder
Synonym(s):
α1-Proteinase inhibitor
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25 MG
1.970,00 kr.
100 MG
7.350,00 kr.
500 MG
35.610,00 kr.
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Product Name
α1-Antitrypsin from human plasma, salt-free, lyophilized powder
biological source
human plasma
form
salt-free, lyophilized powder
concentration
≥60% (biuret)
technique(s)
inhibition assay: suitable
storage temp.
2-8°C
Quality Level
Gene Information
human ... ELA2(1991), ELANE(1991), SERPINA1(5265)
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This Item | A9024 | A2221 | SRP6313 |
|---|---|---|---|
| biological source human plasma | biological source human plasma | biological source human plasma | biological source human |
| Gene Information human ... ELA2(1991), ELANE(1991), SERPINA1(5265) | Gene Information human ... ELA2(1991), SERPINA1(5265) | Gene Information human ... SERPINC1(462) | Gene Information human ... SERPINF2(5345) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level - |
| form salt-free, lyophilized powder | form salt-free, lyophilized powder | form lyophilized powder | form lyophilized |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| concentration ≥60% (biuret) | concentration - | concentration - | concentration - |
Biochem/physiol Actions
≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
Disclaimer
Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Preparation Note
Chromatographically prepared and partially purified.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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J M Bender et al.
Experimental mechanics, 61(1), 235-251 (2021-03-30)
Myxomatous mitral valve degeneration is a common cause of mitral regurgitation and is often associated with mitral valve prolapse. With no known targets to pharmacologically treat mitral valve prolapse, surgery is often the only treatment option. Recently, radiofrequency ablation has
Tian-Hui Yang et al.
Journal of immunology (Baltimore, Md. : 1950), 201(5), 1389-1399 (2018-07-20)
Proteinase 3 (P3), a serine protease expressed by myeloid cells, localized within azurophil granules, and also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN), is the target of autoimmunity in granulomatosis with polyangiitis. PR1, an HLA-A2 restricted nonameric peptide
Kathirvel Alagesan et al.
Analytical and bioanalytical chemistry, 409(2), 529-538 (2016-12-03)
Glycopeptide enrichment is a crucial step in glycoproteomics for which hydrophilic interaction chromatography (HILIC) has extensively been applied due to its low bias towards different glycan types. A systematic evaluation of applicable HILIC mobile phases on glycopeptide enrichment efficiency and
Yukako Oda et al.
Science advances, 7(47), eabj6895-eabj6895 (2021-11-18)
[Figure: see text].
Cynthia L Bristow et al.
Journal of immunology (Baltimore, Md. : 1950), 180(1), 492-499 (2007-12-22)
To identify positive or negative factors for HIV-1 infectivity, clones from the U937 promonocytic cell line that express similar levels of CD4 and CXCR4, but differ in HIV-1 susceptibility, were compared. In contrast to HIV-1 permissive clone 10 (plus), nonpermissive
Articles
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
Related Content
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What is the carbohydrate content of human alpha-1-Antitrypsin?
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We have found the information on alpha-1-antitrypsin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.The alpha-1-antitrypsin is 12 percent carbohydrate, citing K. Heide and H.G. Schwick, Chemistry and Significance of the Carbohydrate Moieties of Human Serum Glycoproteins, Angew. Chem., Int. Ed. Eng., 12, 721-733 (1973).The table also gives information on the percentage of each type of monosaccharide that is present.
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