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Applications:Solid phase extraction

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Two Distinct Sample Prep Approaches to Overcome Matrix Effect in LC/MS of Serum or Plasma Samples

This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.

The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE

Improvement in LC/MS Analysis of Vitamin D Metabolites in Serum by Leveraging Column Selectivity and Effective Sample Prep

A Comparison of Solid Phase Extraction (SPE) Products Used to Purify Peanut Paste Extract for Aflatoxin Analysis

Supel Tox AflaZea SPE produced exceptional analyte recoveries with good reproducibility for all aflatoxins while requiring less than half the sample volume required by competing products.HPLC analysis of all spiked samples after SPE cleanup showed that all compared SPE cartridges

Solid Phase Extraction: Reversed-Phase Methodology

Reversed-phase interaction will retain most molecules with hydrophobic character; it is very useful for extracting analytes that are very diverse in structure within the same sample.

SPE Cleanup of Wheat Extracts Prior to the HPLC Analysis of the Mycotoxin Deoxynivalenol

Supel Tox DON SPE cartridges required fewer process steps and fewer reagents than the IAC cleanup method for wheat matrix samples prior to HPLC analysis.

Replace Classical Liquid-Liquid Extractions with EXtrelut® NT

Simplify your liquid-liquid extractions with our emulsion-free supported-liquid extraction (SLE) single step solution.

The Effect of Container Materials on Production of Light Induced Off-Flavors in Milk – A Study Using SPME-GC-MS

Various plastics used as barriers to the production of off-flavors in light exposed milk were examined using HS-SPME with a new Carboxen®/PDMS coated Nitinol fiber followed by GC-MS analysis allowing detection of low MW analytes at levels <1 ng/mL.

Vitamin D epi-Metabolites Separated with HybridSPE-Phospholipid

This Sigma-Aldrich article continues to detail new methodology for the analysis of Vitamin D metabolites using HybridSPE-Phospholipid technology.

Chiral and Achiral LC-MS Analysis of Warfarin™ in Plasma Samples

Clinical laboratories are beginning to reap the benefits of LC-MS in terms of its sensitivity, specificity, throughput, and potential to reduce cost per sample. The purpose of this study was to demonstrate the LC-MS analysis of Warfarin in plasma samples

Supel-Select HLB SPE for Pharmaceutical Analysis

Select HLB SPE is a hydrophilic polymer phase for analyte extraction from aqueous matrices. Here it’s used for statins in plasma and 48 pharmaceutical analytes in drinking water.

HybridSPE-Phospholipid Technology

This Sigma-Aldrich article discusses how the HybridSPE-Phospholipid Technology works and how the phospholipids are removed.

Aminoglycoside Analysis in Pork Muscle using Molecularly Imprinted Polymer Cleanup and LC/MS/MS Detection

Extraction and quantitative analysis of aminoglycosides in porcine tissue, using molecular imprinted polymer solid phase extraction followed by LC-MS/MS.

Supel™ Swift HLB SPE Cartridges ‒ Solid Phase Extraction (SPE) Made Easy

Supel™ Swift HLB SPE is a polymeric sorbent with lipophilic and hydrophilic functional groups used for solid phase extraction of a wide range of analytes with different polarities. It saves time, offers faster flow rates, and minimum signal enhancement/suppression.

Ion-Exchange SPE Methodology

Normal-Phase Methodology in Solid Phase Extraction Microbiology. In order g003572 for polar retention to occur between the sorbent and the sample, the analyte must be introduced to the SPE device in a non-polar sample or mobile phase environment.

Ion Exchange Methodology

Ion Exchange Methodology in Sold Phase Extraction, Counter Ion Selectivity & Ion Exchange and the basic steps.

HybridSPE®-Phospholipid Technology

Innovative solid phase extraction (SPE) technology from Supelco, utilizes phospholipid retention mechanism based on highly selective interaction between proprietary zirconia ions (bonded to the stationary phase) and the phosphate moiety consistent with phospholipids and proteins.

Extraction of Nitroimidazoles from Milk and Eggs using Molecularly Imprinted Polymers

In this report, SupelMIP SPE – Nitroimidazoles was evaluated for the extraction of nitroimidazoles and metabolites from milk and egg.

Impact of Mobile Phase Additives on LC-MS Sensitivity, Demonstrated using Spice Cannabinoids

This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.

Molecularly Imprinted Polymer SPE- Acid NSAIDs from Muscle

A new, successfully developed and validated LC-MS-MS method allowing the extraction of NSAIDs from poultry muscle tissue using Molecularly Imprinted Polymer (MIP) SPE.

Online Solid Phase Extraction and LC/MS Analysis of Thyroid Hormones in Human Serum

An online SPE-LC/MS method has been developed for the rapid detection of thyroid hormones in human serum with minimal hands on effort and time-consuming steps.

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

Determination of Formaldehyde and Acetaldehyde in Air Using DNPH Cartridges and Automated On-Line Desorption Followed by HPLC

Carbonyl compounds react within the DNPH cartridge to form immobilized hydrazones, which can be subjected to automated desorption and HPLC analysis with UV detection.

Analysis of Drugs of Abuse in Urine After Cleanup with HLB Solid Phase Extraction 96-well Plates

This article validates the ability to perform cleanup of urine samples using HLB solid-phase extraction (SPE) for the analysis of opioids via tandem mass spectrometry (LC-MS/MS) after cleanup with the Supel™ Swift HLB 96-well plate.

Sample Cleanliness Using BioSPME

Learn about Supel™ BioSPME C18 96-pin tool to prepare a clean sample with minimal matrix effects for an LC-MS/MS analysis from human plasma and its comparison with acetonitrile-based precipitation.

Molecularly Imprinted Polymer SPE Increases Sensitivity for the Extraction of Clenbuterol from Urine

In this report, we demonstrated the extraction of SupelMIP SPE – Clenbuterol method against a published hydrophilic polymer SPE method for the trace extraction of clenbuterol from urine for subsequent LC-MS-MS analysis.

Mixed-Mode SPE Improves Extraction of Pharmaceutical Compounds from Biological Fluids

Investigating Matrix Interference in Analysis of Antiarrhythmic Cardiac Drugs in Plasma

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need

Solid Phase Extraction (SPE) Overview

Solid phase extraction is a form of digital (step-wise) chromatography designed to extract, partition, and/or adsorb one or more components from a liquid phase (sample) onto stationary phase (sorbent or resin).

LC/MS/MS Method for Determination of Glyphosate, AMPA, and Glufosinate in Cereals

Glyphosate and related compounds are measured in oatmeal and infant cereal using ion-exchange polymer-based particles for HPLC and SPE. Low level detection was obtained.

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