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Pharmaceutical Secondary Standard; Certified Reference Material

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, Nimodipine
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
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PubChem Substance ID:

Quality Level


certified reference material
pharmaceutical secondary standard


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


pharmaceutical (small molecule)



pharmacopeia traceability

traceable to BP 651
traceable to PhEur N0850000
traceable to USP 1463858

storage temp.


SMILES string




InChI key


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General description

Nimodipine is a well-known calcium antagonist and is a moderate cerebral vasodilator, in addition to being an inhibitor of cerebrovascular reactivity. It is suggested to be cytoprotective by causing a decrease in the influx of calcium into the nerve cells. It is accepted for use in the management of delayed ischaemic dysfunction and is commonlly used in the studies of brain function impairment and dementia in old age.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nimodipine can be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by various electrochemical and spectrophotometric techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAA0583 in the slot below. This is an example certificate only and may not be the lot that you receive.


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Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.
Pickard JD, et al.
BMJ (Clinical Research ed.), 298(6674), 636-642 (1989)
Nitrogen-doped graphene modified electrode for nimodipine sensing
Lei W, et al.
Sensors and Actuators B, Chemical, 212(1), 207-213 (2015)
Assay of nimodipine-an anti hypertensive drug, in bulk form and pharmaceutical formulations by cathodic adsorptive stripping voltammetry
Gupta VK, et al.
International Journal of Electrochemical Science, 6(1), 37-51 (2011)
Enantiospecific determination of nimodipine in human plasma by liquid chromatography-tandem mass spectrometry
Muck WM
Journal of Chromatography A, 712(1), 45-53 (1995)
The atomic absorption spectrophotometric method for indirect determination of nimodipine in tablets
Canlica M and Islimyeli S
Turkish Journal of Chemistry, 29(2), 141-146 (2005)

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