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Nai-Jung Chiang et al.
Clinical and experimental pharmacology & physiology, 41(10), 830-837 (2014-06-10)
Membrane electroporation (MEP) increases the electrical conductivity of the plasma membrane by addition of an external electrical field. Combining MEP-induced current (IMEP ) with antineoplastic agents has been increasingly considered as a new therapeutic manoeuvre, especially in the treatment of
Josue Haubrich et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(2), 315-326 (2014-07-17)
The capacity to adapt to new situations is one of the most important features of memory. When retrieved, memories may undergo a labile state that is sensitive to modification. This process, called reconsolidation, can lead to memory updating through the
Daniel B L Teh et al.
Development, growth & differentiation, 56(8), 583-594 (2014-10-07)
In the adult hippocampus, new neurons are continuously generated and incorporated into the local circuitry in a manner dependent on the network activity. Depolarization evoked by neurotransmitters has been assumed to activate L-type Ca2+ channels (LTCC) which regulate the intracellular
R Grobe-Einsler
Clinical neuropharmacology, 16 Suppl 1, S39-S45 (1993-01-01)
This overview describes the result of the clinical development program in organic brain syndrome (impaired brain function in old age), where efficacy was proven in 11 double-blind, placebo-controlled studies. Another study within this development program showed nimodipine not only to
Nicole Schöbel et al.
Chemical senses, 39(6), 471-487 (2014-04-11)
Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The neural correlates and cellular mechanisms of astringency perception are still not well understood. We explored taste and
Meghan MacKenzie et al.
The Canadian journal of hospital pharmacy, 67(5), 358-365 (2014-11-05)
Aneurysmal subarachnoid hemorrhage is a significant cause of death and disability. Nimodipine 60 mg administered enterally every 4 h improves neurologic outcomes in these patients. However, hypotension is an adverse effect of nimodipine and is believed to prompt clinicians to
Tian-Dong Leng et al.
CNS neuroscience & therapeutics, 21(1), 32-39 (2014-08-30)
Previous study demonstrated that overstimulation of TRPM7 substantially contributes to zinc-mediated neuronal toxicity. Inhibition of TRPM7 activity and TRPM7-mediated intracellular Zn(2+) accumulation may represent a promising strategy in the treatment of stroke. To investigate whether local anesthetics lidocaine could inhibit
Sarah Y Branch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9310-9318 (2014-07-11)
Substantia nigra dopamine neurons are involved in behavioral processes that include cognition, reward learning, and voluntary movement. Selective deterioration of these neurons is responsible for the motor deficits associated with Parkinson's disease (PD). Aging is the leading risk factor for
Shaum S Sridharan et al.
The Laryngoscope, 125(1), 186-190 (2014-09-18)
To retrospectively determine optimal timing for initiation of nimodipine within a cohort of patients with acute vocal fold paralysis (VFP). Retrospective patient review. Subjects were divided into three groups: initiation within 15 days postinjury (n = 19), between 15 and
P Ortega et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 21-29 (2014-12-03)
Membrane pathway for intracellular cadmium (Cd(2+)) accumulation is not fully elucidated in many organisms and has not been studied in crab gill cells. To characterize membrane Cd(2+) transport of anterior and posterior gill cells of Ucides cordatus, a hypo-hyper-regulating crab
Shoko Horibe et al.
Neuroscience research, 87, 33-39 (2014-07-16)
Visual cortical neurons undergo depression and potentiation of their visual responses to stimulation of the deprived and non-deprived eyes, respectively, after monocular deprivation. This modification occurs predominantly during an early postnatal period in normal development, and this critical period is
Potential interactions between nimodipine and adrenal hormones.
R L Isaacson et al.
Annals of the New York Academy of Sciences, 765, 134-142 (1995-09-15)
Camillo Sherif et al.
Acta neurochirurgica. Supplement, 120, 203-207 (2014-11-05)
Delayed vasospasm (VSP) following aneurysmal subarachnoid hemorrhage (aSAH) remains a major source of morbidity. Milrinone was recently suggested as an invasive VSP treatment option. It is a phosphodiesterase III inhibitor with vasodilating and additional positive inotrope and anti-inflammatory effects. In
J Horn et al.
Stroke, 32(10), 2433-2438 (2001-10-06)
Based on the results of animal experiments, clinical trials were performed with nimodipine, which did not demonstrate a beneficial effect on outcome after stroke. The aim of this study was to determine whether the evidence from animal experiments with nimodipine
W Mück et al.
Die Pharmazie, 49(2-3), 130-139 (1994-02-01)
The analytical test procedures currently established for the determination of the dihydropyridine calcium antagonist nimodipine in biological fluids are presented. Method of choice which has been dominantly used in pharmacokinetic investigations and drug interaction studies is gas chromatography with electron-capture
[Piracetam, nimodipine and tacrine in the pharmacologic treatment of dementia: bibliographic review].
D Ojer Tsakiridu et al.
Atencion primaria, 18(5), 257-260 (1996-09-30)
Yao Li et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(10), 1706-1714 (2014-08-08)
Cerebral parenchymal arterioles (PAs) have a critical role in assuring appropriate blood flow and perfusion pressure within the brain. They are unique in contrast to upstream pial arteries, as defined by their critical roles in neurovascular coupling, distinct sensitivities to
Samuel J Rose et al.
Experimental neurology, 261, 553-562 (2014-08-12)
Episodic ataxia type 2 (EA2) is an autosomal dominant disorder associated with attacks of ataxia that are typically precipitated by stress, ethanol, caffeine or exercise. EA2 is caused by loss-of-function mutations in the CACNA1A gene, which encodes the α1A subunit
M C de Jonge et al.
Clinical neuropharmacology, 16 Suppl 1, S25-S30 (1993-01-01)
Over the years, it has become apparent that many cytotoxic events employ a common pathway in destroying cells, namely the disruption of calcium homeostasis. Further studies show that the aging process is also accompanied, perhaps even partly caused, by changes
Sarah E Gullbrand et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(12), 1694-1700 (2014-09-05)
Intervertebral disc health is mediated in part by nutrient diffusion from the microvasculature in the adjacent subchondral bone. Evidence suggests that a reduction in nutrient diffusion contributes to disc degeneration, but the role of the microvasculature is unclear. The purpose
José-Carlos Fernández-Morales et al.
American journal of physiology. Cell physiology, 307(5), C455-C465 (2014-07-06)
At early life, the adrenal chromaffin cells respond with a catecholamine surge under hypoxic conditions. This response depends on Ca(2+) entry through voltage-activated calcium channels (VACCs). We have investigated here three unresolved questions that concern this response in rat embryo
A Kakarieka et al.
Journal of neural transmission. Supplementum, 43, 13-21 (1994-01-01)
Increased intracellular calcium is involved in the death of neurons associated with cerebral ischemia. After extensive experimental work, the calcium antagonist nimodipine has been investigated in several clinical trials in patients with disorders of the cerebral circulation. A short overview
Nima Etminan et al.
Acta neurochirurgica. Supplement, 120, 281-286 (2014-11-05)
The effective reduction of delayed cerebral ischemia (DCI), a main contributor for poor outcome following aneurysmal subarachnoid hemorrhage (SAH), remains challenging. Previous clinical trials on systemic pharmaceutical treatment of SAH mostly failed to improve outcome, probably because of insensitive pharmaceutical
Allan Kjeldsen Hansen et al.
Journal of neurophysiology, 112(3), 631-643 (2014-09-25)
Behavior-associated theta-frequency oscillation in the hippocampal network involves a patterned activation of place cells in the CA1, which can be accounted for by a somatic-dendritic interference model predicting the existence of an intrinsic dendritic oscillator. Here we describe an intrinsic
Joanna Kur et al.
Investigative ophthalmology & visual science, 55(5), 2893-2902 (2014-04-05)
To investigate the mechanisms responsible for the dilatation of rat retinal arterioles in response to arachidonic acid (AA). Changes in the diameter of isolated, pressurized rat retinal arterioles were measured in the presence of AA alone and following pre-incubation with
Nimodipine for peripheral nerve recovery after maxillofacial and vestibular schwannoma surgery.
Konstanze Scheller et al.
Muscle & nerve, 50(6), 1026-1027 (2014-09-27)
Mervyn D I Vergouwen et al.
The Lancet. Neurology, 5(12), 1029-1032 (2006-11-18)
Despite several randomised controlled trials, there is still much debate whether nimodipine improves outcome in patients with traumatic subarachnoid haemorrhage. A 2003 Cochrane review reported improved outcome with nimodipine in these patients; however, because the results of Head Injury Trial
M N Carvi y Nievas
Neurological research, 21(7), 649-652 (1999-11-11)
The use of calcium antagonists has been advocated as decreasing morbidity and mortality in patients with subarachnoid hemorrhage (SAH) following aneurysm rupture. Results reported from open or placebo-controlled studies show a wide variation with regard to outcome. The immediate clipping
Bin Pan et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 290-300 (2014-06-04)
Sigma-1 receptor (σ1R), an endoplasmic reticulum-chaperone protein, can modulate painful response after peripheral nerve injury. We have demonstrated that voltage-gated calcium current is inhibited in axotomized sensory neurons. We examined whether σ1R contributes to the sensory dysfunction of voltage-gated calcium
J M López-Arrieta et al.
The Cochrane database of systematic reviews, (3)(3), CD000147-CD000147 (2002-07-26)
Dementia is an age-associated syndrome most commonly due to Alzheimer's disease (AD) and/or cerebrovascular disease. Calcium has an important role in regulating brain functions. Calcium ions link membrane excitation to subsequent intracellular molecular responses. Age-associated changes in calcium homoeostasis have
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