Lithium bis(trimethylsilyl)amide (LHMDS) is a non-nucleophilic strong base widely used in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is generally soluble in most nonpolar organic solvents.
Lithium bis(trimethylsilyl)amide solution (1.0 M in THF) can be used as a base in directed aldol condensations and Darzens condensation reactions; α-arylation of aryl ester derivatives and allylic amination reaction. LHMDS is a preferred base for the generation of kinetic enolates than sodium hexamethyldisilazide (NaHMDS) because the enolates produced are more regiostable than those produced with NaHMDS.
4×25, 100, 4×100, 800 mL in Sure/Seal™
1 L in Sure/Seal™
8, 18 L in Kilo-Lab™
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
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