Merck
All Photos(6)

733857

Sigma-Aldrich

DL-α-Tocopherol methoxypolyethylene glycol succinate solution

greener alternative

2 wt. % in H2O

Synonym(s):
TPGS-750-M
Linear Formula:
(C2H4O)nC34H56O5
CAS Number:

form

liquid

Quality Level

reaction suitability

reagent type: catalyst
reaction type: Bucherer Carbazole Synthesis

reagent type: surfactant

greener alternative product characteristics

Catalysis
Learn more about the Principles of Green Chemistry.

concentration

2 wt. % in H2O

refractive index

n20/D 1.336

density

1.002 g/mL at 25 °C

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product TPGS-750-M is a lead surfactant for many transition metal-catalyzed cross-couplings and has been enhanced for catalytic efficiency. Find details here.
Learn More at the Professor and Product Portal of Professor Bruce Lipshutz.

Application

Second generation amphiphile which forms micelles upon dissolution in water allowing a variety of cross-coupling reactions to take place in water instead of organic solvent.

Included among the possible reactions are:
  • Olefin metathesis
  • Pd-catalyzed cross coupling reactions including Heck, Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig reactions
  • C-H activation reactions

Second generation amphiphile for cross-coupling reactions in water

Packaging

10, 50, 100, 500 mL in glass bottle

Other Notes

Watch Professor Lipshutz talk about TPGS-750-M in this webinar:
From milligrams to kilograms: synthetic chemistry following nature′s lead

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Articles

TPGS-750-M: Second-Generation Amphiphile for Organometallic Chemistry in Water at Room Temperature

Lipshutz and co-workers have recently developed a second generation technology to their original PTS-enabling surfactant based on the polyoxyethanyl-α-tocopheryl succinate derivative, TPGS-750-M.

Protocols

Suzuki-Miyaura Reaction in Water at Room Temperature using TPGS-750-M

TPGS-750-M, a second generation surfactant, may be used for Suzuki-Miyaura Reactions in Water at Room Temperature

Buchwald-Hartwig Amination Reaction in Water at Room Temperature using TPGS-750-M

Buchwald-Hartwig Amination Reaction in Water at Room Temperature using TPGS-750-M

Related Content

Lipshutz Group – Professor Product Portal

Prof. Bruce Lipshutz and co-workers have developed designer surfactants to allow several classes of transformations (e.g. Suzuki-Miyaura, Olefin Metathesis, 1,4-Addition to Enones, etc.) to be performed in water.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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