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92361

Sigma-Aldrich

Chlorotrimethylsilane

≥98.0% (GC)

Synonym(s):
Trimethylsilyl chloride, TMCS, Trimethylchlorosilane
Linear Formula:
(CH3)3SiCl
CAS Number:
Molecular Weight:
108.64
Beilstein:
970119
Beilstein:
1209232
EC Number:
EC Number:
MDL number:
MDL number:
PubChem Substance ID:

Quality Level

vapor density

<1 (vs air)
3.7 (vs air)

vapor pressure

100 mmHg ( 25 °C)
1 mmHg ( 51 °C)

assay

≥98.0% (GC)

autoignition temp.

752 °F

expl. lim.

6.4 %

refractive index

n20/D 1.62 (lit.)
n20/D 1.387 (lit.)

bp

196 °C (lit.)
57 °C (lit.)

mp

54-58 °C (lit.)
−40 °C (lit.)

solubility

water: soluble 81.7 g/L at 20 °C

density

1.62 g/mL at 25 °C (lit.)
0.856 g/mL at 25 °C (lit.)

SMILES string

C[Si](C)(C)Cl
OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

InChI key

IJOOHPMOJXWVHK-UHFFFAOYSA-N
YNJBWRMUSHSURL-UHFFFAOYSA-N

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General description

Trichloroacetic acid (TCA) is a chlorinated acetic acid. It is one of the major metabolites of trichloroethylene (TCE).
Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Application

Chlorotrimethylsilane has been used to silanize glass surface to make them more hydrophobic. It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation reaction. Also used in Fisher Glycosylation
Trichloroacetic acid may be used in the following studies:
  • Estimation of phosphorus in various biological samples (serum, urine and stool ash solutions).
  • Elimination of acid-soluble and lipid phosphorous during the determination of deoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues.
  • Preparation of 2-methyl-4-nitroanilinium trichloroacetate trichloroacetic acid (2M4NATCA) crystals.

10% Trichloroacetic acid may be employed for the preparation of radioactive proteins.
Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Packaging

1 L in glass bottle
100, 500 mL in glass bottle

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-18.4 °F - closed cup

Flash Point(C)

-28 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations, 4, 261-261 (2014)
Thermal analysis of disulfonated poly (arylene ether sulfone) plasticized with poly (ethylene glycol) for membrane formation.
Oh HJ, et al.
Polymer, 55(1), 235-247 (2014)
Yuma Komata et al.
Chemistry, an Asian journal, 11(22), 3225-3233 (2016-10-21)
Alkoxychlorosilanes are scientifically and industrially important toward preparing silicone and silica as well as preparation of siloxane-based nanomaterials by stepwise reactions of Si-OR (R=alkyl) and Si-Cl groups. Intermolecular exchange of alkoxy and chloro groups between alkoxysilanes and chlorosilanes (functional group...
Yongju Kwon et al.
Nature communications, 11(1), 3127-3127 (2020-06-21)
Magic-sized clusters (MSCs) can be isolated as intermediates in quantum dot (QD) synthesis, and they provide pivotal clues in understanding QD growth mechanisms. We report syntheses for two families of heterogeneous-atom-incorporated InP MSCs that have chlorine or zinc atoms. All...
Use of organosilicon reagents as protective groups in organic synthesis.
Lalonde M & Chan TH.
Synthesis, 1985(09), 817-845 (1985)

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