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330707

Avanti

SPLASH® LIPIDOMIX® Mass Spec Standard

SPLASH® LIPIDOMIX® Mass Spec Standard, methanol solution

NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (330707-1EA)

concentration

1 mg/mL (330707-1EA)

shipped in

dry ice

storage temp.

−20°C

General description

Make a splash in your lab and dive right into Lipidomics with our easy to use mixture of deuterium labeled lipids. The SPLASH® LIPIDOMIX® Mass Spec Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. This internal standard mixture was developed in collaboration with Kim Ekroos (Zora Biosciences).

Application

SPLASH® LIPIDOMIX® Mass Spec Standard has been used:
  • as an internal standard for non-alcoholic fatty liver disease (NAFLD) signature analysis from mice and human samples
  • as an internal standard in the quantification of phospholipids from duodenum, liver, and adipose tissue using ultra performance liquid chromatography quadrupole-time of-flight mass spectrometry (UPLC-q-Tof MS)
  • in human cell lines prior to lipid analysis by liquid chromatography-mass spectrometry (LC-MS) analysis

Features and Benefits

  • Save time: pre-mixed internal standards.
  • Save money: 1 vial is sufficient for 100 plasma samples.
  • Exact concentrations provided for quantitative lipidomic analysis.
  • Applicable to multiple MS approaches.
  • Concentration of each lipid class optimized for plasma analysis.

Packaging

2 mL Amber Glass Sealed Ampule (330707-1EA)

Components

The SPLASH LIPIDOMIX Mass Spec Standard is supplied in 1 mL of methanol and contains the following components:

Mixture ComponentTarget Conc. (μg/mL)
  • 15:0-18:1(d7) PC160
  • 15:0-18:1(d7) PE5
  • 15:0-18:1(d7) PS5
  • 15:0-18:1(d7) PG30
  • 15:0-18:1(d7) PI10
  • 15:0-18:1(d7) PA7
  • 18:1(d7) LPC25
  • 18:1(d7) LPE5
  • 18:1(d7) Chol Ester350
  • 18:1(d7) MG2
  • 15:0-18:1(d7) DG10
  • 15:0-18:1(d7)-15:0 TG55
  • 18:1(d9) SM30
  • Cholesterol (d7)100

Legal Information

LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.
SPLASH is a registered trademark of Avanti Polar Lipids, Inc.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 2

Flash Point F

49.5 °F - closed cup

Flash Point C

9.7 °C - closed cup

Certificate of Analysis

Certificate of Origin

Isabelle E Logan et al.
Microorganisms, 8(4) (2020-04-09)
A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesis that Swiss Webster...
Naren Gajenthra Kumar et al.
PloS one, 13(10), e0206606-e0206606 (2018-11-01)
Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the potential for use in developing...
Bernhard Drotleff et al.
Analytical and bioanalytical chemistry (2020-01-17)
Dental plaque is a structurally organized biofilm which consists of diverse microbial colonies and extracellular matrix. Its composition may change when pathogenic microorganisms become dominating. Therefore, dental biofilm or plaque has been frequently investigated in the context of oral health...
Bobbie-Jo M Webb-Robertson et al.
Analytical chemistry, 92(2), 1796-1803 (2019-11-20)
Advancements in molecular separations coupled with mass spectrometry have enabled metabolome analyses for clinical cohorts. A population of interest for metabolome profiling is patients with rare disease for which abnormal metabolic signatures may yield clues into the genetic basis, as...
Michal Holčapek et al.
Analytical chemistry, 90(7), 4249-4257 (2018-03-16)
The state-of-art in the lipidomic analysis is summarized here to provide the overview of available sample preparation strategies, mass spectrometry (MS)-based methods for the qualitative analysis of lipids, and the quantitative MS approaches for high-throughput clinical workflows. Major challenges in...

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