All Photos(2)

700087P

Avanti

DHEA

Dehydroepiandrosterone, powder

Synonym(s):
DHEA; 3β-hydroxy-5-androsten-17-one; 5-androsten-3β-ol-17-one; dehydroisoandrosterone; trans-dehydroandrosterone; Prasterone
Empirical Formula (Hill Notation):
C19H28O2
CAS Number:
Molecular Weight:
288.42
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (700087P-1g)

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

InChI key

FMGSKLZLMKYGDP-USOAJAOKSA-N

General description

Dehydroepiandrosterone (DHEA) is a carbon (C)-19 neuroactive steroid. It is synthesized by the adrenal gland in humans and mammals.
DHEA (dehydroepiandrosterone) is an endogenous steroid hormone secreted by the adrenal gland. DHEA serves as precursor to male and female sex hormones (androgens and estrogens).
25-hydroxy-cholesterol is a metabolite of cholesterol. It is produced by macrophages.

Biochem/physiol Actions

25-hydroxy-cholesterol represses the production of IgA by B cells, manages the migration of activated B cells in the germinal follicle. It regulates the differentiation of monocytes into macrophages. 25-hydroxy-cholesterol plays a critical role in lipid biosynthesis and immunity. It inhibits sterol regulatory element-binding protein (SREBP) proteolytic processing and modulates cholesterol metabolism.
Dehydroepiandrosterone (DHEA) regulates neural functions, such as neurogenesis, neuroprotection, neuronal growth and differentiation. It is used to treat multiple sclerosis. DHEA acts as a precursor of sex steroid biosynthesis.

Packaging

20 mL Clear Glass Screw Cap Vial (700087P-1g)

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Repr. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Certificate of Analysis

Certificate of Origin

Sex Hormones in Neurodegenerative Processes and Diseases (2018)
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
Shibata N, et al.
The Journal of biological chemistry, 288(50), 35812-35823 (2013)
25-Hydroxycholesterol: a new life in immunology
McDonald JG and Russell DW
Journal of Leukocyte Biology, 88(6), 1071-1072 (2010)
Joseph S Dillon
Current drug targets. Inflammation and allergy, 4(3), 377-385 (2005-08-17)
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids. DHEA(S) and closely related steroid hormones have a variety of immunological effects both in vitro and in vivo in...
Marco Racchi et al.
CNS drug reviews, 9(1), 21-40 (2003-02-22)
The physiological role of dehydroepiandrosterone (DHEA) and its sulphated ester DHEA(S) has been studied for nearly 2 decades and still eludes final clarification. The major interest in DHEA derives from its unique pattern of activity. Its levels exhibit a dramatic...

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