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880120P

Avanti

18:0 PEG2000 PE

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt), powder

CAS Number:

form

powder

packaging

pkg of 1 × 1 g (880120P-1g)
pkg of 1 × 200 mg (880120P-200mg)
pkg of 1 × 25 mg (880120P-25mg)
pkg of 1 × 500 mg (880120P-500mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is conjugate, covalently attached to polyethylene glycol (PEG2000). It forms a stable micelle of 180kDa with phosphoethanolamine as hydrophobic core and hydrophilic PEG2000 as outer micelle surface.

Application

18:0 PEG2000 PE may be used in the nickel resin functionalization of quantum dots. It may also be used in liposome preparation.

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is an effective drug carrier and is biocompatible. PEG stabilizes and protects the micelle from phagocytic system. The use of PEG as a conjugate with phospholipids enables improved liposome preparation and effective drug encapsulation.

Packaging

5 mL Amber Glass Screw Cap Vial (880120P-200mg)
5 mL Amber Glass Screw Cap Vial (880120P-25mg)
20 mL Clear Glass Screw Cap Vial (880120P-500mg)
20 mL Clear Glass Screw Cap Vial (880120P-1g)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Certificate of Analysis

Certificate of Origin

Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media
Vukovic L, et al.
Journal of the American Chemical Society, 133(34), 13481-13488 (2011)
Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes
Graham SM, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 178, 101-107 (2014)
Relationship between targeting efficacy of liposomes and the dosage of targeting antibody using surface plasmon resonance
Xiang Y, et al.
Langmuir, 31(44), 12177-12186 (2015)
P A Melnikov et al.
Bulletin of experimental biology and medicine (2019-11-24)
We studied the effect of IL-1β on the permeability of brain capillaries in healthy mice. Intravital microscopy demonstrated that parenteral administration of IL-1β was followed by an increase in vascular permeability ensuring passage of free Alexa488 fluorescent label through the...
Ling Ye et al.
Nanotheranostics, 3(1), 54-65 (2019-01-22)
Rationale: Despite growing use of engineered nanomaterials (ENM) in applications from electronics to medicine, the potential risk to human health remains a critical concern within clinical use. ENM exposure during pregnancy can potentially cause reproductive toxicity even at levels that...

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