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880151P

Avanti

DMG-PEG 2000

1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, powder

Empirical Formula (Hill Notation):
C122H242O50
CAS Number:
Molecular Weight:
2509.20
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (880151P-1G)
pkg of 1 × 5 g (880151P-5G)

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC

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General description

Structure, molecular formula and formula weight are representative of the average polymer length of the material.
Dimyristoyl glycerol (DMG) molecule associates with membrane similar to phospholipids.

Application

DMG-PEG 2000 is suitable for use in the preparation of lipid nanoparticle for microRNA and short interfering RNA delivery.

Biochem/physiol Actions

Dimyristoyl glycerol (DMG) − polyethyleneglycol (PEG) 2000 is used for liposome preparation for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma. It is also used in lipid nanoparticle preparation for siRNA (small interfering RNA) delivery.

Packaging

20 mL Clear Glass Screw Cap Vial (880151P-1G)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (880151P-5G)

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificate of Analysis

Certificate of Origin

Dynamic chain conformations in dimyristoyl glycerol-dimyristoyl phosphatidylcholine mixtures. 2H-NMR studies
Schorn K and Marsh D
Biophysical Journal, 71(6), 3320-3329 (1996)
Liver-Specific silencing of Lipin1 reduces fat mass as well as hepatic triglyceride biosynthesis in mice
Kajimoto K, et al.
Biological & Pharmaceutical Bulletin, 39(10), 1653-1661 (2016)
miR-199a-3p modulates MTOR and PAK4 pathways and inhibits tumor growth in a hepatocellular carcinoma transgenic mouse model
Callegari E, et al.
Molecular Therapy. Nucleic Acids, 11(3), 485-493 (2018)
Advances in lipid nanoparticles for siRNA delivery
Tam Y, et al.
Pharmaceutics, 5(3), 498-507 (2013)
Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia
Huang X, et al.
Clinical Cancer Research, 19(9), 2355-2367 (2013)

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