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890890P

Avanti

18:1 TAP (DOTAP)

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), powder

Empirical Formula (Hill Notation):
C42H80NO4Cl
CAS Number:
Molecular Weight:
698.54
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 g (890890P-1g)
pkg of 2 × 100 mg (890890P-200mg)
pkg of 5 × 100 mg (890890P-500mg)
pkg of 1 × 25 mg (890890P-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

Application

18:1 TAP (DOTAP) has been used in chloroform solutions to form dry film in the preparation of cationic liposomes. It has also been used in standard stock solution used for the preparation of cationic liposomes.

Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890890P-200mg)
5 mL Clear Glass Sealed Ampule (890890P-500mg)
5 mL Clear Glass Sealed Ampule (890890P-25mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (890890P-1g)

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis
Li Y, et al.
BMC Pharmacology & Toxicology, 19(1), 43-43 (2018)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
Analysis of cationic liposomes by reversed-phase HPLC with evaporative light-scattering detection
Zhong Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 51(4), 947-951 (2010)
Elias J Sayour et al.
Nano letters, 18(10), 6195-6206 (2018-09-28)
Translation of nanoparticles (NPs) into human clinical trials for patients with refractory cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome these limitations, simple well-characterized mRNA lipid-NPs have been developed as cancer immunotherapeutic vaccines. While...

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