PHR1748

Glacial Acetic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Acetic acid, Glacial acetic acid
• Linear Formula: CH₃CO₂H
• CAS Number: 64-19-7
• Molecular Weight: 60.05
• Beilstein: 506007
• EC Number: 200-580-7
• MDL number: MFCD00036152
• PubChem Substance ID: 329823593
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1005706
• vapor density: 2.07 (vs air)
• API family: glacial acetic acid
• CofA: current certificate can be downloaded
• autoignition temp.: 800 °F
• expl. lim.: 16 %, 92 °F; 4 %, 59 °F
• packaging: ampule of 3x1.5 mL
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.371 (lit.)
• bp: 117-118 °C (lit.)
• mp: 16.2 °C (lit.)
• density: 1.049 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CC(O)=O
• InChI: 1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)
• InChI key: QTBSBXVTEAMEQO-UHFFFAOYSA-N

Description

General description

Glacial Acetic Acid is a simple monocarboxylic acid, which is devoid of water. Pharmaceutically, it is commonly used as a topical antibiotic that treats infections caused by bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Glacial Acetic Acid may be used as a reference standard for the determination of the analyte in raw materials and pharmaceutical formulations by titrimetry and gas chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2954 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226 - H314
• Precautionary Statements: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 102.2 °F
• Flash Point(C): 39 °C