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C1231

SAFC

Cholesterol, Plant-Derived

SyntheChol®

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Synonym(s):
Cholesterol, Synthetic cholesterol, 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
Empirical Formula (Hill Notation):
C27H46O
CAS Number:
Molecular Weight:
386.65
Beilstein:
1915888
EC Number:
MDL number:

biological source

synthetic

Quality Level

Agency

JP
NF
Ph. Eur.

Assay

≥98%

form

crystals

bp

360 °C (lit.)

mp

147-149 °C (lit.)

density

1.067 g/mL at 25 °C (lit.)

suitability

suitable for manufacturing use

shipped in

dry ice

storage temp.

−20°C (−15°C to −25°C)

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

Gene Information

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This Item
C8503C8667C3045
Cholesterol, Plant-Derived SyntheChol®

SAFC

C1231

Cholesterol, Plant-Derived

Cholesterol from sheep wool, ≥92.5% (GC), powder

Sigma-Aldrich

C8503

Cholesterol

Cholesterol Sigma Grade, ≥99%

Sigma-Aldrich

C8667

Cholesterol

Cholesterol powder, BioReagent, suitable for cell culture, ≥99%

Sigma-Aldrich

C3045

Cholesterol

assay

≥98%

assay

≥92.5% (GC)

assay

≥99%

assay

≥99%

form

crystals

form

powder

form

powder

form

powder

bp

360 °C (lit.)

bp

360 °C (lit.)

bp

360 °C (lit.)

bp

360 °C (lit.)

mp

147-149 °C (lit.)

mp

147-149 °C (lit.)

mp

147-149 °C (lit.)

mp

147-149 °C (lit.)

density

1.067 g/mL at 25 °C (lit.)

density

1.067 g/mL at 25 °C (lit.)

density

1.067 g/mL at 25 °C (lit.)

density

1.067 g/mL at 25 °C (lit.)

Biochem/physiol Actions

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Preparation Note

Synthesized from material of non-animal origin

Legal Information

SyntheChol is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR
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Journal of internal medicine, 277(3), 331-342 (2014-04-24)
Liver-selective thyromimetic agents could provide a new approach for treating dyslipidaemia. We performed a multicentre, randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of eprotirome, a liver-selective thyroid hormone receptor agonist, in 98 patients with primary hypercholesterolaemia. After
Michael J Pencina et al.
The New England journal of medicine, 370(15), 1422-1431 (2014-03-22)
The 2013 guidelines of the American College of Cardiology and the American Heart Association (ACC-AHA) for the treatment of cholesterol expand the indications for statin therapy for the prevention of cardiovascular disease. Using data from the National Health and Nutrition
Steven A Grover et al.
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Despite the increased risk of cardiovascular disease and type 2 diabetes associated with excess bodyweight, development of a clinically meaningful metric for health professionals remains a challenge. We estimated the years of life lost and the life-years lost from diabetes

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