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F8758

Sigma-Aldrich

Folic acid

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

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Synonym(s):
Pterylmonoglutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
Beilstein:
100781
EC Number:
MDL number:
eCl@ss:
34058014
PubChem Substance ID:
NACRES:
NA.75

biological source

synthetic

Quality Level

product line

BioReagent

Assay

≥97%

form

powder

mol wt

Mw 441.40 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

dark yellow

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange

storage temp.

room temp

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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This Item
F7876F8798PHR1035
Folic acid BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Sigma-Aldrich

F8758

Folic acid

Folic acid ≥97%

Sigma-Aldrich

F7876

Folic acid

Folic acid meets USP testing specifications

Sigma-Aldrich

F8798

Folic acid

Folic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1035

Folic acid

assay

≥97%

assay

≥97%

assay

97.0-102.0% dry basis

assay

-

form

powder

form

powder

form

solid

form

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

dark yellow

color

faint orange to dark orange-yellow, faint yellow to dark yellow

color

yellow

color

-

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange

solubility

-

solubility

-

solubility

-

General description

Folic acid (FA)/pterylmonoglutamic acid helps to block neural tube defects (NTDs).

Application

Folic acid has been used:
  • to study the role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
  • in cells and treatments
  • in perforin gene targeting using the CRISPR/Cas gene editing approach

Biochem/physiol Actions

A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Folic acid handling by the human gut: implications for food fortification and supplementation
Patanwala I, et al.
American Journal of Clinical Nutrition, 100(2), 593-599 (2014)
Reduced expression of galectin-9 contributes to a poor outcome in colon cancer by inhibiting NK cell chemotaxis partially through the Rho/ROCK1 signaling pathway
Wang Y, et al.
PloS one, 11(3), e0152599-e0152599 (2016)
Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study
Li Z, et al.
International Journal of Epidemiology, 43(4), 1132-1139 (2014)
Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2
Sevim H, et al.
Stem Cell Research & Therapy, 9(1), 198-198 (2018)
The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
Ducommun P, et al.
Cytotechnology, 37(2), 65-73 (2001)

Articles

Importance and uses of folic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures. Folic acid and its reduced derivative(s), such as folinic acid, are an essential water soluble vitamins added to virtually all cell culture media.

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