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Lipopolysaccharides from Escherichia coli O55:B5

purified by phenol extraction

EC Number:
MDL number:

Quality Level

biological source

Escherichia coli (O55:B5)


lyophilized powder

purified by

phenol extraction


<3% Protein (Lowry)

shipped in


storage temp.


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General description

Lipopolysaccharides (LPSs) consist of a lipid A moiety linked to an antigenic O-polysaccharide.


Lipopolysaccharide from Escherichia coli O55:B5 has been used:
  • to stimulate hepatocytes and non-parenchymal cells
  • to stimulate the spleen and study the expression of the Malitaf gene in the fish blunt snout bream
  • as part of the concanavalin A (ConA) and D-galactosamine/lipopolysaccharide (D-GalN/LPS) model of fulminant hepatitis to study the effect of the natural compound hesperetin
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).


10 mg in poly bottle
25, 100, 500 mg in glass bottle

Biochem/physiol Actions

Lipid A plays a role in the biological properties attributed to endotoxic LPS. LPS is a highly immunogenic antigen which has the ability to enhance immune responses.


Skull and crossbones

Signal Word


Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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A liver microphysiological system of tumor cell dormancy and inflammatory
responsiveness is affected by scaffold properties
Clark AM
Cancer Discovery null
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Xueting Bai
British Journal of Pharmacology, 174 (2017)
H T L Lai et al.
Poultry science, 90(2), 337-351 (2011-01-21)
Earlier, we reported that pathogen-associated molecular patterns such as lipopolysaccharide (LPS), when administered intratracheally (i.t.), affected primary and secondary specific antibody responses to antigens administered concurrently, either i.t. or systemically, and also affected BW gain (BWG) of layers and broilers.
Identification and Characterization of Lipopolysaccharide Induced TNFa Factor from Blunt Snout Bream, Megalobrama amblycephala
Yina LV
International Journal of Molecular Sciences, 18(2), 233-233 (2017)
Novel adjuvants & delivery vehicles for vaccines development: a road ahead.
Mohan T
The Indian Journal of Medical Research, 138(5), 779-795 (2013)


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