Drug Delivery Formulations and Technologies
Step-by-step Instructions for Nanoformulation Development
Drug delivery formulation and particle synthesis made simple
Drug delivery formulations are essential for the delivery, efficacy and stability of many active pharmaceutical ingredients (APIs) and have become exceedingly important with recent advancements in therapeutics, including mRNA vaccines and other nucleic acids.
Our NanoFabTx™ formulation kits are designed for facile and reproducible synthesis of nano- to micro-sized drug-loaded particles. Detailed protocols with step-by-step instructions are provided for nanoformulation development, eliminating the need for lengthy trial-and-error optimization. NanoFabTx™ formulation kits and lipid mixes can be used with traditional nanoprecipitation or extrusion methods or can be combined with the NanoFabTx™ microfluidic device kits for rapid synthesis of well-defined drug delivery particles.
Products
Microneedle template
15x15 array, H 600 μm, base size 200 μm, 500µm pitch
Lithium phenyl-2,4,6-trimethylbenzoylphosphinate
≥95%
Hyaluronic acid
acid form, average Mw 25,000
Gelatin methacryloyl
gel strength 300 g Bloom, 80% degree of substitution
NanoFabTx™ microfluidic - nano
device kit for synthesis of 100-200 nm nanoparticles and liposomes
NanoFabTx™ NanoFlash CIJ device
for nanoparticle synthesis
Poly(D,L-lactic-co-glycolic acid)-block-poly(glutamic acid)
PLGA average Mn 25,000, mol wt (PGlu average Mn 5,000), lactide:glycolide 50:50
Microneedle spring applicator set
Poly(glycerol sebacate)
NanoFabTx™ PLGA-nano
for synthesis of 100 and 200 nm particles
NanoFabTx™ microfluidic - micro
device kit for synthesis of 10-30 μm particles
NanoFabTx™ microfluidic - micro
device kit for synthesis of 1-5 μm particles
Microneedle template
10x10 array, H 500 μm, base size 150 μm, 500 µm pitch
Aldehyde functionalized hyaluronic acid
Degree of functionalization ~40%
Polysuccinimide
≥95%, average Mw 60000
Microneedle loader set
Poly(propylene fumarate)
contains contains ~20 wt% diethyl fumarate & 250 ppm MEHQ as inhibitor
NanoFabTx™ PLA-nano
for synthesis of 100 and 200 nm particles
NanoFabTX™-DOTAP Lipid Mix
for synthesis of cationic (DOTAP) liposomes
NanoFabTx™ PEG-PLGA drug formulation screening kit
for synthesis of PEGylated nanoparticles
NanoFabTx™ Polymer Drug Formulation Kits for Drug-Encapsulated Particles Synthesis
Our NanoFabTx™ Drug Formulation Kits are designed to prepare specifically-sized polymeric micro- and nanoparticles for small molecule drug delivery. Each kit contains rationally selected polymers developed and tested by our formulation scientists. Our NanoFabTx™ Formulation Screening Kits make polymer selection and optimization easy by providing multiple polymers to choose from including PEGylated and non-PEGylated biodegradable polymers PLA, PLGA, and PCL.
NanoFabTx™ Lipid Mixes for Liposome Production
Liposomes are widely used for a range of therapeutics including small molecules, nucleic acids (mRNA, siRNA, DNA), proteins, and peptides. Our NanoFabTx™ lipid formulation mixes are curated lipid blends for liposome preparation. We offer a variety of lipid mixes to best suit your nanoformulation needs including PEGylated, cationic, and functionalized liposomes.
NanoFabTx™ Microfluidic Device Kits for Polymeric and Lipid Nanoparticle Synthesis
Microfluidic devices provide a platform for rapid and reproducible microparticle, nanoparticle, lipid nanoparticle, and liposome fabrication. Unlike traditional methods, microfluidics-based nanoparticle synthesis results in controlled particle size and small size distribution and can easily be scaled up to produce larger batch sizes needed for preclinical trials.
Our NanoFabTx™ microfluidic device kits include a pre-assembled microfluidic glass chip, tubing and accessories and can be directly connected to a syringe pump or pressurized pump system, such as Dolomite Microfluidics Mitos P-Pump. The NanoFabTx™ microfluidic device kits are designed to work together with our NanoFabTx™ drug formulation kits and lipid mixes.
Related Resources
- Article: NanoFabTx™ – A ready-to-use Microfluidic Platform for mRNA Vaccine Formulation
Knappett, Gray and researcher introduce NanoFabTx™: A ready-to-use microfluidic platform for mRNA vaccine formulation. NanoFabTx™ reagent and microfluidic device kits provide a ready-to-use platform to screen multiple formulations, and ultimately synthesize mRNA or drug-encapsulated liposomes for preclinical assessments.
- Article: NanoFabTx™ Nanoparticle and mRNA Liposome Formulation Using the NanoAssemblr®
NanoFabTX drug delivery formulation kits and lipids mixes for mRNA, nucleic acid, and small molecule delivery in lipid nanoparticles, liposomes and polymeric nanoparticles prepared using Precision NanoSystems microfluidic NanoAssemblr
- PDF: Material Matters 14.3 – Advanced Tools for Drug Delivery Research
Nanoparticle drug delivery systems are emerging as a useful tool for achieving controlled and targeted delivery of drug molecules and thereby enhancing therapeutic effect. The cover art for this issue depicts microfluidic-assisted nanoformulation, one method for fabricating liposomes and polymeric nanoparticles for the delivery of smallmolecule and biological drugs.
- Brochure: The Future of Drug Delivery: Lyophilized Liposome Flyer
Liposomes are one of the most common drug delivery carriers for small molecules and nucleic acid therapeutics.
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