Genetic Screening

Genetic Screening

Screening Tools at the Scale to Meet Your Goals.

Functional genomics screens offer unique insight into the complex genetic pathways underlying drug resistance and disease but designing a screening experiment can feel daunting. With unmatched experience in lentivirus and the largest portfolio of screening products on the market, Sigma-Aldrich® Advanced Genomics will help ensure you have all the right tools to meet your research goals.

With over 350 years of technical leadership, Sigma-Aldrich® Advanced Genomics products come with expertise that extends Beyond the Bench—from discovery to therapeutic impact.

Powerful Screening Tools for All Your Needs

The Sigma-Aldrich® Advanced Genomics screening portfolio has been designed to provide you with a complete range of tools to enable your target discovery. Our functional genomics screens were developed with trusted partners including The Broad Institute, UCSF, The Wellcome Trust Sanger Institute and 10x Genomics.

Whether you’re looking at gene knockout, investigating loss-of-function, gain-of-function, or using a combination of gene perturbation methods, our superior range of functional genomics and gene modulation screens can be used for even the most difficult targets.

Gene Knockout Screens

Investigate the whole genome, or customize to interrogate the gene families of your choice with our trusted pooled CRISPR knockout screens and our exclusive Sanger arrayed KO screen:

Gene Inhibition/Knockdown Screens

The MISSION® shRNA Library includes comprises the TRC1, and exclusive TRC1.5 and TRC2 collections to provide unparalleled gene coverage. Developed using UCSF designs, our whole genome CRISPRi libraries are also available as off-the shelf subpools and with 10x Genomics Feature Barcoding for single cell discovery:

Gene Activation/Overexpression Screens

Our SAM CRISPRa libraries and pools, developed by the Broad Institute, have demonstrated superior activation particularly for difficult-to-express targets. Our ORF screens are available in both pooled and arrayed formats and with puromycin selection:

Ready-to-use Custom Lentiviral Screens

Preparing lentivirus can be tricky, let us to do the hard work for you. Our expert lentiviral manufacturing capabilities also enable you to select specific vector options optimized for your experiment.

Single Cell Analysis & Deconvolution

Identify hits from your pooled screens using our deconvolution services, or track your gene perturbations at single cell resolution using our 10x Genomics certified compatible products:

We’re Here to Help

Whether you need help designing your screening experiment, require assistance troubleshooting, or simply want to better understand how lentiviral screening can enhance your research, Sigma-Aldrich® Advanced Genomics is here to guide you. Connect with a Sigma-Aldrich® Advanced Genomics Expert.

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Highlights

CRISPR-based Screening
Advantages of Transcriptional Activators and Inhibitors

CRISPR Screening Tips
A simple modification to improve CRISPR-pooled screening result. Reduce NGS noise by eliminating artifact DNA.

Learn how to understand, design and perform CRISPR experiments, as well as design gRNA, choose a Cas9 format, screen with CRISPR, use advanced CRISPR formats, and much more…
Gene Editing 101 eBook

A free eBook designed to help you understand, design, and perform CRISPR experiments. Download your copy now!

Download your CRISPR Screening infographic
Download your CRISPR Screening infographic

CRISPR-based functional genomics screening provides a broad overview of the genetic contributions to a measurable phenotype.