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Naren Gajenthra Kumar et al.
PloS one, 13(10), e0206606-e0206606 (2018-11-01)
Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the potential for use in developing
Bernhard Drotleff et al.
Analytical and bioanalytical chemistry (2020-01-17)
Dental plaque is a structurally organized biofilm which consists of diverse microbial colonies and extracellular matrix. Its composition may change when pathogenic microorganisms become dominating. Therefore, dental biofilm or plaque has been frequently investigated in the context of oral health
Isabelle E Logan et al.
Microorganisms, 8(4) (2020-04-09)
A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesis that Swiss Webster
Diana Széliová et al.
Methods in molecular biology (Clifton, N.J.), 2088, 119-160 (2020-01-02)
Biomass composition is an important input for genome-scale metabolic models and has a big impact on their predictive capabilities. However, researchers often rely on generic data for biomass composition, e.g. collected from similar organisms. This leads to inaccurate predictions, because
Bo Burla et al.
Journal of lipid research, 59(10), 2001-2017 (2018-08-18)
Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the
Bobbie-Jo M Webb-Robertson et al.
Analytical chemistry, 92(2), 1796-1803 (2019-11-20)
Advancements in molecular separations coupled with mass spectrometry have enabled metabolome analyses for clinical cohorts. A population of interest for metabolome profiling is patients with rare disease for which abnormal metabolic signatures may yield clues into the genetic basis, as
Denise Wolrab et al.
Analytical and bioanalytical chemistry, 412(10), 2375-2388 (2020-02-23)
Ultrahigh-performance supercritical fluid chromatography-mass spectrometry (UHPSFC/MS) has a great potential for the high-throughput lipidomic quantitation of biological samples; therefore, the full optimization and method validation of UHPSFC/MS is compared here with ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC/MS) in hydrophilic interaction liquid
Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation
Ackerman D, et al.
Cell Reports, 24(10), 2596-2605 (2018)
Michal Holčapek et al.
Analytical chemistry, 90(7), 4249-4257 (2018-03-16)
The state-of-art in the lipidomic analysis is summarized here to provide the overview of available sample preparation strategies, mass spectrometry (MS)-based methods for the qualitative analysis of lipids, and the quantitative MS approaches for high-throughput clinical workflows. Major challenges in
Lei Chen et al.
Gastroenterology, 158(4), 985-999 (2019-11-25)
Functions of intestinal stem cells (ISCs) are regulated by diet and metabolic pathways. Hepatocyte nuclear factor 4 (HNF4) family are transcription factors that bind fatty acids. We investigated how HNF4 transcription factors regulate metabolism and their functions in ISCs in
Jeffrey Molendijk et al.
Biomolecules, 10(5) (2020-05-21)
Esophageal adenocarcinoma (EAC) incidence has been rapidly increasing, potentially associated with the prevalence of the risk factors gastroesophageal reflux disease (GERD), obesity, high-fat diet (HFD), and the precursor condition Barrett's esophagus (BE). EAC development occurs over several years, with stepwise
Finnur Freyr Eiriksson et al.
PloS one, 15(4), e0231289-e0231289 (2020-04-15)
Breast cancer (BC) is the most prevalent type of cancer in women in western countries. BC mortality has not declined despite early detection by screening, indicating the need for better informed treatment decisions. Therefore, a novel noninvasive diagnostic tool for
Isha H Jain et al.
Cell, 181(3), 716-727 (2020-04-08)
Human cells are able to sense and adapt to variations in oxygen levels. Historically, much research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive oxygen species (ROS). Here, we perform genome-wide CRISPR growth screens at 21%
Mike Lange et al.
Analytical and bioanalytical chemistry, 412(15), 3573-3584 (2020-04-03)
Lipidomics analysis for large-scale studies aiming at the identification and quantification of natural lipidomes is often performed using LC-MS-based data acquisition. However, the choice of suitable LC-MS method for accurate lipid quantification remains a matter of debate. Here, we performed
Genetic regulation of plasma lipid species and their association with metabolic phenotypes
Jha P, et al.
Cell Systems, 6(6), 709-721 (2018)
Hyemin Lee et al.
Nature cell biology, 22(2), 225-234 (2020-02-08)
Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation
Tomoki Naito et al.
eLife, 8 (2019-11-15)
Cholesterol is a major structural component of the plasma membrane (PM). The majority of PM cholesterol forms complexes with other PM lipids, making it inaccessible for intracellular transport. Transition of PM cholesterol between accessible and inaccessible pools maintains cellular homeostasis
Valerie Z Wall et al.
Journal of lipid research, 58(6), 1174-1185 (2017-04-19)
Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells. Enzymatic thioesterase
Metabolomics Profile and Targeted Lipidomics in Multiple Tissues Associated with Feed Efficiency in Beef Steers
Artegoitia VM, et al.
ACS Omega, 4(2), 3973-3982 (2019)
M A López-Bascón et al.
Analytical and bioanalytical chemistry, 412(2), 489-498 (2019-11-25)
Polar lipids, especially glycerophospholipids, constitute the main components of cell membranes and are precursors of signaling molecules in many cellular and physiological processes. For this reason, the development of methods with high capability for detection of polar lipids in biological
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