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Xuemei Fang et al.
Toxicology, 294(2-3), 109-115 (2012-03-06)
Exposure to perfluorononanoic acid (PFNA), an increasingly persistent organic pollutant that has been detected in abiotic and biotic matrices, has been demonstrated to cause hepatotoxicity in animals. However, the effects of PFNA on hepatic glucose metabolism have not been fully
Xiaowei Sun et al.
Journal of chromatography. A, 1623, 461197-461197 (2020-06-09)
Trifluoromethyl covalent organic framework (CF3-COF) is facilely synthesized at room temperature using for solid-phase microextraction (SPME). The CF3-COF coating displays an improved extraction performance for per- and polyfluorinated alkyl substances (PFASs) comparing to amorphous polymer coating, non-contained fluorine covalent organic
Michael A Wheeler et al.
Cell, 176(3), 581-596 (2019-01-22)
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational
Zhuyu Sun et al.
Chemosphere, 174, 127-135 (2017-02-06)
Perfluoroalkyl acids (PFAAs) have been found to be ubiquitously disseminated in the environment due to their widespread use in recent decades. In this study, the occurrence and spatiotemporal distribution of PFAAs in the surface water of Huangpu River, Shanghai, China
Eugenia Pasanisi et al.
The Science of the total environment, 572, 1059-1065 (2016-08-16)
Lepidochelys olivacea is the most abundant and globally distributed sea turtle species in the world and thus, monitoring this species for persistent organic pollutants, such as perfluorinated chemicals, is fundamental for their protection. This study was the first to evaluate
Fei Li et al.
Chemosphere, 200, 124-132 (2018-02-25)
The anaerobic biodegradability and metabolic pathways of 8:2 fluorotelomer alcohol (8:2 FTOH) were investigated in anaerobic activated sludge. The biodegradation was well described by a double exponential decay model. 8:2 FTOH was biodegraded to poly- and perfluorinated metabolites with the
Anna Mattsson et al.
Scientific reports, 9(1), 19808-19808 (2019-12-26)
Perfluoroalkyl acids (PFAAs) are ubiquitous environmental contaminants and eggs and nestlings of raptors and fish-eating birds often contain high levels of PFAAs. We studied developmental effects of a mixture of ten PFAAs by exposing chicken embryos to 0.5 or 3 μg/g
Ruth Halsne et al.
Toxicology letters, 259, 95-107 (2016-08-12)
Perfluorinated alkyl acids (PFAAs) are stable chemicals detected in tissue and serum from various species, including humans, and have been linked to adverse health outcomes. Experimental PFAA exposure in rodents has been associated with changes in mammary gland development. The
Run-Chao Lu et al.
Colloids and surfaces. B, Biointerfaces, 64(1), 98-103 (2008-03-01)
The interactions of proteins with fluorinated/hydrogenated surfactants were investigated by circular dichroism and turbidity measurement. Pairs of fluorinated and hydrogenated surfactants with similar critical micelle concentrations (cmc), including sodium perfluorooctanoate/sodium decylsulfate and lithium perfluorononanoate/sodium dodecylsulfate were compared in view of
Qian Chen et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 224, 117362-117362 (2019-07-29)
In this work, a novel strategy for perfluorooctane sulfonic acid (PFOS) detection was established by using a ratiometric nanosensor with the combination of fluorescence and second-order scattering (SOS). The practical ratiometric nanosensor was synthesized simply by mixing fluorescent dye ethidium
B O Fagbayigbo et al.
Environmental monitoring and assessment, 190(6), 346-346 (2018-05-17)
In this study, an analytical method for the routine determination of nine perfluorinated compounds (PFCs), using ultra performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer (UPLC-QTOF-MS), was developed, validated, and used for their assay in surface water and
Marleen Maras et al.
Environmental health perspectives, 114(1), 100-105 (2006-01-06)
We investigated estrogen-like properties of five perfluorinated compounds using a combination of three in vitro assays. By means of an E-screen assay, we detected the proliferation-promoting capacity of the fluorotelomer alcohols 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) and 1H,1H,2H,2H-perfluoro-decan-1-ol (8:2 FTOH). The more
Xuemei Fang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 108(2), 367-376 (2009-02-07)
Perfluorononanoate (PFNA), a perfluorinated alkyl acid containing nine carbon chains, has been detected in abiotic and biotic matrices worldwide. Although a few studies have reported toxic effects of PFNA, little information of the mechanism has been offered. In this study
John L Newsted et al.
Environmental toxicology and chemistry, 36(11), 3138-3147 (2017-06-20)
In 2011, poly- and perfluoroalkyl substances (PFASs) were analyzed in surface water and fish fillet samples taken from Pool 2 of the Upper Mississippi River, a 33-mile stretch inclusive of the Minneapolis/St. Paul, Minnesota (USA) metropolitan area. Approximately 100 each
Eva Gorrochategui et al.
Analytica chimica acta, 854, 20-33 (2014-12-07)
A lipidomic study was developed in a human placental choriocarcinoma cell line (JEG-3) exposed to tributyltin (TBT) and to a mixture of perfluorinated chemicals (PFCs). The method was based on the application of multivariate curve resolution-alternating least squares (MCR-ALS) to
Xuemei Fang et al.
Archives of toxicology, 86(10), 1515-1525 (2012-06-01)
Kupffer cells (KCs) have been demonstrated to play a role in the regulation of intra-hepatic lipid metabolism through the synthesis and secretion of biologically active products. The involvement of KCs in the disturbance of lipid metabolism that induced by perfluorononanoic
C M Goecke-Flora et al.
Chemical research in toxicology, 9(4), 689-695 (1996-06-01)
Using nuclear magnetic resonance (NMR) spectroscopy, we investigated the importance of carbon chain length with regard to the hepatic effects associated with perfluoro-n-carboxylic acids. Male F-344 rats were administered a single intraperitoneal dose of either perfluoro-n-heptanoic acid (C7-PFA), perfluoro-n-nonanoic acid
Lianying Zhang et al.
Toxicology and applied pharmacology, 279(3), 275-283 (2014-07-08)
Perfluorinated compounds (PFCs) have been shown to disrupt lipid metabolism and even induce cancer in rodents through activation of peroxisome proliferator-activated receptors (PPARs). Lines of evidence showed that PPARα was activated by PFCs. However, the information on the binding interactions
N Kudo et al.
Chemico-biological interactions, 124(2), 119-132 (2000-02-12)
The potency of the induction of peroxisomal beta-oxidation was compared between perfluorinated fatty acids (PFCAs) with different carbon chain lengths in the liver of male and female rats. In male rats, perfluoroheptanoic acid (PFHA) has little effect, although perfluorooctanoic acid
Changhui Liu et al.
Environmental toxicology and chemistry, 33(10), 2323-2332 (2014-07-06)
Concerns regarding perfluorinated chemicals (PFCs) have risen in recent years because of their ubiquitous presence and high persistency. However, data on the environmental impacts of PFCs on marine organisms are very limited. Oxidative toxicity has been suggested to be one
Jonathan E Naile et al.
Chemosphere, 144, 1722-1728 (2015-11-01)
Perfluoroalkyl substances are globally distributed in both urban and remote settings, and routinely are detected in wildlife, humans, and the environment. One of the most prominent and routinely detected perfluoroalkyl substances is perfluorooctanoic acid (PFOA), which has been shown to
Jordan Stubleski et al.
Environment international, 95, 86-92 (2016-08-21)
Poly- and perfluoroalkyl substances (PFASs) are a group of man-made fluorinated chemicals which have, at background levels, been associated with negative health effects in humans. Thus far, most human biomonitoring studies have evaluated the general change in PFAS concentration over
H T Piao et al.
Chemosphere, 179, 387-394 (2017-04-09)
The Grand Canal, also known as the Beijing-Hangzhou Grand Canal, is a UNESCO World Heritage Site and the longest canal in the world. It is an important trunk line of the South-to-North Water Diversion Project in China. The contamination status
Yoko Shiwaku et al.
Chemosphere, 164, 603-610 (2016-09-17)
This study was conducted to clarify the spatial distributions of perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA) in well, surface and tap water around a fluoropolymer plant in Osaka between 2003 and 2016 and to predict the fate of those
Huiming Cao et al.
Environmental science & technology, 53(5), 2811-2819 (2019-02-09)
Perfluorooctanesulfonate (PFOS) is a persistent organic pollutant with significant bioaccumulation potential in liver tissues. Exposure to PFOS could cause increase of liver weight, induce adenomas of the liver, and cause hepatomegaly. Alternatives of PFOS might be designed and synthesized that
Ewa Poboży et al.
Mikrochimica acta, 172(3-4), 409-417 (2011-04-08)
Perfluorinated carboxylic acids (PFCAs) represent an important group of persistent perfluorinated organic compounds commonly determined in environmental and biological samples. A reversed-phase HPLC method was developed based on derivatization of the PFCAs with the commercially available fluorescent reagent 3-bromoacetyl coumarin.
Juan Zhang et al.
Soft matter, 14(40), 8231-8238 (2018-10-05)
The effects of alkyl chain length of anionic fluorinated fatty acid surfactants, CnF2n+1COOH (n = 7-11), mixed with one cationic hydrocarbon surfactant, tetradecyltrimethylammonium hydroxide (TTAOH), on the formation of polyhedral vesicle gels were investigated in aqueous solutions. On the basis
Katoria Tatum-Gibbs et al.
Toxicology, 281(1-3), 48-55 (2011-01-18)
Perfluorononanoic acid (PFNA) is a fluorinated organic chemical found at low levels in the environment, but is detectable in humans and wildlife. The present study compared the pharmacokinetic properties of PFNA in two laboratory rodent species. Male and female Sprague-Dawley
Natasha D White et al.
The Science of the total environment, 521-522, 79-89 (2015-04-02)
Urban areas are sources of perfluoroalkyl substances (PFASs) in the environment, although little is known about specific point sources and distribution of PFASs. Sentinel species, like bottlenose dolphins, are important indicators of environmental perturbations. The high PFAS levels found in
Ruijuan Qu et al.
Water research, 104, 34-43 (2016-08-11)
Decomposition of perfluorocarboxylic acids (PFCAs) is of great significance due to their global distribution, persistence and toxicity to organisms. In this study, the photodegradation of a series of PFCAs (∼C2C12) in water by a medium-pressure mercury lamp was experimentally and
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