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Keitaro Sou et al.
Scientific reports, 9(1), 17991-17991 (2019-12-01)
Thermosensitive fluorescent dyes can convert thermal signals into optical signals as a molecular nanoprobe. These nanoprobes are playing an increasingly important part in optical temperature sensing and imaging at the nano- and microscale. However, the ability of a fluorescent dye
Qing Wang et al.
Biophysical journal, 115(4), 664-678 (2018-08-08)
Using Förster resonance energy transfer, raft/liquid-ordered-domain formation was assessed in asymmetric vesicles containing outer leaflets composed of high-Tm (melting temperature) saturated phosphatidylcholines (diC18:0PC, diC16:0PC, diC15:0PC, or diC14:0PC), low-Tm unsaturated dioleoylphosphatidylcholine (DOPC) and cholesterol, and inner leaflets composed of lipids that
Claudia Caviglia et al.
Analytical and bioanalytical chemistry (2020-05-27)
Evaluation and understanding the effect of drug delivery in in vitro systems is fundamental in drug discovery. We present an assay based on real-time electrical impedance spectroscopy (EIS) measurements that can be used to follow the internalisation and cytotoxic effect
Manxiang Wu et al.
Cancer management and research, 11, 9387-9395 (2019-12-07)
Ultrasound-targeted microbubble destruction (UTMD) has been shown to be a promising noninvasive technique to change the tumor circulation, thus providing a potential method to increase reactive oxygen species (ROS) levels in tumors by inducing tumor tissue ischemia-reperfusion (IR). In this
Investigating the structure of multicomponent gel-phase lipid bilayers
Hartkamp R, et al.
Biophysical Journal, 111(4), 813-823 (2016)
Frederick J Tan et al.
Protein science : a publication of the Protein Society, 20(1), 62-74 (2010-10-30)
Bcl-2 proteins associate with and remodel mitochondria to regulate apoptosis. While the C. elegans Bcl-2 homolog CED-9 constitutively associates with mitochondria, it is unclear whether or not this association reflects an innate ability of CED-9 to directly remodel mitochondrial membranes.
Kirian Talló et al.
Journal of materials chemistry. B, 8(1), 161-167 (2019-11-30)
A hydrogel formed with phospholipids and fatty acids would be of great interest in the medical field due to the biological relevance that these molecules have in living organisms. However, the tendency of phospholipid mixtures to form vesicular or micellar
Baksun Kim et al.
Nanoscale, 12(21), 11672-11683 (2020-05-22)
B cell malignancies, such as B cell leukemia and lymphoma, have CD22 overexpression with ∼7% of patients. A short CD22 binding peptide (PV3) with a moderate affinity (Kd ∼ 9 μM) was identified by screening multiple peptide candidates determined through
Maryam T Hussain et al.
International journal of pharmaceutics, 573, 118722-118722 (2019-11-11)
Technology such as the use of microfluidics to generate liposomes has been well researched, yet the stabilisation of liposomal formulations is a major challenge to their greater implementation. To the best of our knowledge, this is the first study investigating
Kevin A Carter et al.
Nature communications, 5, 3546-3546 (2014-04-05)
The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential to selectively enhance localized delivery. Here we describe liposomes doped with porphyrin-phospholipid that are permeabilized directly by near-infrared
Graham J Taylor et al.
Langmuir : the ACS journal of surfaces and colloids, 33(38), 10016-10026 (2017-08-16)
In-plane lipid organization and phase separation in natural membranes play key roles in regulating many cellular processes. Highly cooperative, first-order phase transitions in model membranes consisting of few lipid components are well understood and readily detectable via calorimetry, densitometry, and
I Osorio-Querejeta et al.
Pharmaceutics, 12(2) (2020-02-27)
Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by
Tadaharu Suga et al.
Molecular pharmaceutics, 15(10), 4481-4490 (2018-09-05)
High-functionality and -quality (HFQ) lipids have a discrete molecular weight and good water dispersibility and can be produced by solid-phase peptide synthesis. Therefore, HFQ lipids are a promising material for the preparation of ligand-grafted PEGylated liposomes. Recently, we have reported
Liposome layers characterized by quartz crystal microbalance measurements and multirelease delivery
Brochu H and Vermette P
Langmuir, 23(14), 7679-7686 (2007)
Jayesh A Kulkarni et al.
ACS nano, 12(5), 4787-4795 (2018-04-04)
Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, the mechanism of formation and certain structural features of LNP-siRNA remain obscure.
Rathapon Asasutjarit et al.
International journal of pharmaceutics, 577, 119084-119084 (2020-01-29)
Ganciclovir (GCV) is an antiviral drug approved for treatment of cytomegalovirus (CMV) retinitis. It can be delivered to the eye via systemic administrations. However, local delivery of GCV that targets the retina is considered as an alternative to increase efficacy
Marius Maximilian Woitok et al.
Cell death & disease, 11(5), 343-343 (2020-05-13)
Lipid-based RNA nanocarriers have been recently accepted as a novel therapeutic option in humans, thus increasing the therapeutic options for patients. Tailored nanomedicines will enable to treat chronic liver disease (CLD) and end-stage liver cancer, disorders with high mortality and
Richard J Browning et al.
Langmuir : the ACS journal of surfaces and colloids, 36(2), 609-617 (2019-12-20)
Microbubbles stabilized by an outer lipid shell have been studied extensively for both diagnostic and therapeutic applications. The shell composition can significantly influence microbubble behavior, but performing quantitative measurements of shell properties is challenging. The aim of this study is
Yanyan Li et al.
Journal of nanobiotechnology, 17(1), 117-117 (2019-12-01)
Cancer cells always develop ways to resist and evade chemotherapy. To overcome this obstacle, herein, we introduce a programmatic release drug delivery system that imparts avoiding drug efflux and nuclear transport in synchrony via a simple nanostructured drug strategy. The
L Bakás et al.
Biophysical journal, 71(4), 1869-1876 (1996-10-01)
Alpha-Hemolysin is an extracellular protein toxin (107 kDa) produced by some pathogenic strains of Escherichia coli. Although stable in aqueous medium, it can bind to lipid bilayers and produce membrane disruption in model and cell membranes. Previous studies had shown
Sen Ye et al.
Journal of materials chemistry. B, 8(3), 447-453 (2019-12-14)
Thrombotic disease is a serious threat to human health. The rapid and accurate detection of thrombosis is still a clinical challenge. To achieve the accurate diagnosis of thrombosis with magnetic resonance imaging (MRI), nanomaterials-based contrast agents have been developed in
Hongmei Liu et al.
Journal of biomedical nanotechnology, 15(11), 2271-2280 (2019-12-19)
Stem-cell-based therapy has attracted considerable attention due to the significant benefits to patients experiencing a wide range of diseases and injuries. However, their underlying mechanism of action is not completely understood. One main reason is the lack of imaging tools
Ana Reis et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183133-183133 (2019-12-01)
Food polyphenols in fruits juices, tea, coffee, wine and beer confer sensory properties such as colour, astringency and bitterness. The development of functional healthy drinks without the unpleasant sensory feeling is boosting research for a clearer understanding on the interactions
Joshua Owen et al.
Langmuir : the ACS journal of surfaces and colloids, 35(31), 10014-10024 (2018-11-30)
Phospholipid coated microbubbles are currently in widespread clinical use as ultrasound contrast agents and under investigation for therapeutic applications. Previous studies have demonstrated the importance of the coating nanostructure in determining microbubble stability and its dependence upon both composition and
Srinivas Ramishetti et al.
Advanced materials (Deerfield Beach, Fla.), 32(12), e1906128-e1906128 (2020-01-31)
Lipid nanoparticles (LNPs) are the most advanced nonviral platforms for small interfering RNA (siRNA) delivery that are clinically approved. These LNPs, based on ionizable lipids, are found in the liver and are now gaining much attention in the field of
Comparative study of PEGylated and conventional liposomes as carriers for shikonin
Tsermentseli S, et al.
Fluids, 3(2), 36-36 (2018)
Philippe Calvez et al.
Journal of the American Chemical Society (2016-10-01)
Recoverin undergoes a calcium-myristoyl switch during visual phototransduction. Indeed, calcium binding by recoverin results in the extrusion of its myristoyl group, which allows its membrane binding. However, the contribution of particular lipids and of specific amino acids of recoverin in
Olga Sergeeva et al.
Cells, 9(4) (2020-04-30)
Ribosome biogenesis is among the founding processes in the cell. During the first stages of ribosome biogenesis, polycistronic precursor of ribosomal RNA passes complex multistage maturation after transcription. Quality control of preribosomal RNA (pre-rRNA) processing is precisely regulated by non-ribosomal
Huiqing Lv et al.
PloS one, 11(1), e0145195-e0145195 (2016-01-05)
Hepatocellular carcinoma (HCC) remains a global health threat. The search for novel anti-HCC agents is urgent. In the current study, we synthesized a liposomal C8 ceramide, and analyzed its anti-tumor activity in pre-clinical HCC models. The liposomal C8 (ceramide) potently
Jonah S Harmon et al.
Langmuir : the ACS journal of surfaces and colloids, 36(24), 6626-6634 (2020-05-19)
Targeted therapy and molecular imaging using ultrasound have been widely explored using microbubble contrast agents, and more recently, activatable droplet contrast agents that vaporize when exposed to focused ultrasound have been explored. These droplets are coated with a stabilizing, functionalizable
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