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850375P

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Eric H Hill et al.
Langmuir : the ACS journal of surfaces and colloids, 34(44), 13252-13262 (2018-10-24)
Lipid vesicles are important biological assemblies, which are critical to biological transport processes, and vesicles prepared in the lab are a workhorse for studies of drug delivery, protein unfolding, biomolecular interactions, compartmentalized chemistry, and stimuli-responsive sensing. The current method of
Naomi Benne et al.
Advanced healthcare materials, 9(10), e2000043-e2000043 (2020-04-25)
Atherosclerosis is characterized by the retention of lipids in foam cells in the arterial intima. The liver X receptor (LXR) agonist GW3965 is a promising therapeutic compound, since it induces reverse cholesterol transport in foam cells. However, hepatic LXR activation
Keni Yang et al.
Acta biomaterialia, 106, 314-327 (2020-02-23)
Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context
Keishi Suga et al.
Langmuir : the ACS journal of surfaces and colloids, 33(15), 3831-3838 (2017-03-09)
We investigated the effect of organic acids such as mandelic acid (MA) and tartaric acid (TA) on the adsorption behavior of both histidine (His) and propranolol (PPL) onto liposomes. A cationic and heterogeneous liposome prepared using 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/sphingomyelin (SM)/3β-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Ch)
Tess A Stanly et al.
The Journal of biological chemistry, 295(15), 5036-5050 (2020-02-09)
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) mediates the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to its ligand hyaluronan in the leukocyte surface glycocalyx. To bind hyaluronan efficiently, LYVE-1 must undergo surface clustering, a
Lei Li et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 5944-5953 (2020-05-12)
Activation of Raf kinases by the membrane-anchored protein K-Ras4B is a key step of cellular signal regulation. As a predominant variant of the Ras family, K-Ras4B has been considered to be a major drug target in cancer therapy. Therefore, an
Chaohong Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 188(7), 3237-3246 (2012-03-06)
B cells encounter both soluble Ag (sAg) and membrane-associated Ag (mAg) in the secondary lymphoid tissue, yet how the physical form of Ag modulates B cell activation remains unclear. This study compares actin reorganization and its role in BCR signalosome
Madhabi Lata Shuma et al.
Biochemistry, 59(18), 1780-1790 (2020-04-15)
The entry of cell-penetrating peptides (CPPs) into live cells and lipid vesicles has been monitored using probe (e.g., fluorescent dye)-labeled CPPs. However, probe labeling may alter the interaction of CPPs with membranes. We have developed a new method to detect
Véronique Yvette Ntsogo Enguéné et al.
Frontiers in microbiology, 6, 541-541 (2015-06-18)
Efflux pumps are membrane transporters that actively extrude various substrates, leading to multidrug resistance (MDR). In this study, we have designed a new test that allows investigating the assembly of the MexA-MexB-OprM efflux pump from the Gram negative bacteria Pseudomonas
N'Goundo Magassa et al.
EMBO reports, 11(5), 400-405 (2010-03-27)
Bacterial toxin injection into the host cell is required for the virulence of numerous pathogenic bacteria. Cytolysin-mediated translocation (CMT) of Streptococcus pyogenes uses streptolysin O (SLO) to translocate the S. pyogenes nicotinamide adenine dinucleotide-glycohydrolase (SPN) into the host cell cytosol
Mohammad Abu Sayem Karal et al.
Chemistry and physics of lipids, 230, 104916-104916 (2020-05-15)
The interaction of anionic magnetite nanoparticles (MNPs) of size 18 nm with negatively charged giant unilamellar vesicles (GUVs) formed from a mixture of neutral dioleoylphosphatidylcholine (DOPC) and negatively charged dioleoylphosphatidylglycerol (DOPG) lipids has been investigated. It has been obtained that
Yogi Kurniawan et al.
Langmuir : the ACS journal of surfaces and colloids, 29(34), 10817-10823 (2013-07-31)
Cellular adaptation to elevated alcohol concentration involves altering membrane lipid composition to counteract fluidization. However, few studies have examined the biophysical response of biologically relevant heterogeneous membranes. Lipid phase behavior, molecular packing, and elasticity have been examined by surface pressure-area
Oleksandr Kolyvushko et al.
Pathogens (Basel, Switzerland), 9(5) (2020-05-14)
Exposure of phosphatidylserine (PS) in the outer leaflet of the plasma membrane is induced by infection with several members of the Alphaherpesvirinae subfamily. There is evidence that PS is used by the equine herpesvirus type 1 (EHV-1) during entry, but
Mitchell DiPasquale et al.
Biochimica et biophysica acta. Biomembranes, 1862(8), 183189-183189 (2020-01-19)
The antioxidant vitamin E is a commonly used vitamin supplement. Although the multi-billion dollar vitamin and nutritional supplement industry encourages the use of vitamin E, there is very little evidence supporting its actual health benefits. Moreover, vitamin E is now
Role of the biomolecular interactions in the structure and tribological properties of synovial fluid
Mirea D, et al.
Tribology International, 59(5), 302-311 (2013)
Alicia A Nugent et al.
Neuron, 105(5), 837-854 (2020-01-07)
Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms and cell sorting with RNA
Krishnendu Pal et al.
NPJ precision oncology, 3, 31-31 (2019-12-17)
Clear cell renal cell carcinoma (ccRCC) is known for its highly vascular phenotype which is associated with elevated expression of vascular endothelial growth factor A (VEGF), also known as vascular permeability factor (VPF). Accordingly, VEGF has been an attractive target
Yun-Chieh Sung et al.
Nature nanotechnology, 14(12), 1160-1169 (2019-11-20)
Abnormal tumour vasculature has a significant impact on tumour progression and response to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis and, thus, can be delivered to normalize tumour vasculature. However, a NO-delivery system with a prolonged half-life
Takuhiro Otosu et al.
Physical chemistry chemical physics : PCCP, 22(3), 1242-1249 (2019-12-19)
A supported lipid bilayer (SLB) is now an indispensable tool to analyze the dynamical properties of biomembranes. However, the effect of a solid support on the leaflet-specific lipid dynamics in a SLB remains elusive, which hampers the further application of
Max Piffoux et al.
ACS nano, 12(7), 6830-6842 (2018-07-06)
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport macromolecules throughout the body. Hijacking this endogenous communication system represents an attractive strategy for advanced drug delivery. However, efficient and reproducible loading of EVs with therapeutic or imaging agents
John E Gadbery et al.
Biochemistry, 57(36), 5370-5378 (2018-08-21)
Although the interfacial membrane protein cholesterol oxidase is structurally and kinetically well-characterized, its orientation in and mode of interaction with cholesterol-containing membranes have not been established. Cholesterol oxidase can alter the structure of the cell membrane in pathogenic bacteria and
Han-Yuan Liu et al.
Analytical and bioanalytical chemistry (2020-02-06)
We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted lipid bilayer formation method. These supported bilayers present protein recognition elements that are mobile, critical for multivalent
Mahsa Kheradmandi et al.
Cellular and molecular bioengineering, 13(3), 189-199 (2020-05-20)
Atherosclerosis (ATH), the build up of fat in the arteries, is a principal cause of heart attack and stroke. Drug instability and lack of target specificity are major drawbacks of current clinical therapeutics. These undesirable effects can be eliminated by
Md Zahidul Islam et al.
Langmuir : the ACS journal of surfaces and colloids, 33(9), 2433-2443 (2017-02-07)
The translocation of cell-penetrating peptides (CPPs) through plasma membranes of living cells is an important physiological phenomenon in biomembranes. To reveal the mechanism underlying the translocation of a CPP, transportan 10 (TP10), through lipid bilayers, we examined the effects of
Kuan-Wei Huang et al.
Science advances, 6(3), eaax5032-eaax5032 (2020-01-31)
While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader application of cancer immunotherapy. Here, we report a combinatorial immunotherapy approach that uses a highly efficient and
Thomas Berry et al.
Langmuir : the ACS journal of surfaces and colloids, 34(38), 11586-11592 (2018-08-19)
Melimine and its derivatives are synthetic chimeric antimicrobial agents based on protamine and melittin. The binding of solubilized melimine and its derivative, with a cysteine on N-terminus, (cys-melimine) on tethered bilayer lipid membranes (tBLMs) was examined using ac electrical impedance
An Ghysels et al.
Nature communications, 10(1), 5616-5616 (2019-12-11)
The functional significance of ordered nanodomains (or rafts) in cholesterol rich eukaryotic cell membranes has only begun to be explored. This study exploits the correspondence of cellular rafts and liquid ordered (Lo) phases of three-component lipid bilayers to examine permeability.
Han-Yuan Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 36(26), 7325-7331 (2020-05-12)
Transmembrane proteins (TMPs) regulate processes occurring at the cell surface and are essential gatekeepers of information flow across the membrane. TMPs are difficult to study, given the complex environment of the membrane and its influence on protein conformation, mobility, biomolecule
Lucrecia Alberdi et al.
Journal of cell science, 133(9) (2020-05-16)
Salmonella enterica is an intracellular bacterial pathogen. The formation of its replication niche, which is composed of a vacuole associated with a network of membrane tubules, depends on the secretion of a set of bacterial effector proteins whose activities deeply
Keishi Suga et al.
Langmuir : the ACS journal of surfaces and colloids, 29(15), 4830-4838 (2013-03-20)
Nanosized ordered domains formed in 1,2-dioleoyl-sn-glycero-3-phosphocholine/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DOPC/DPPC) and DOPC/cholesterol (Ch) liposomes were characterized using a newly developed (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) quenching method. The membrane fluidity of the DOPC/DPPC liposomes, evaluated by the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), increased significantly above their phase-transition
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